Electrospray systems and methods

Details Electrospray systems and methods Electrospray systems and methods

2007-04-24

2007-04-24

Wells, Nikita (Department: 2881)

Radiant energy

Ionic separation or analysis

Ion beam pulsing means with detector synchronizing means

C250S286000, C250S42300F

Reexamination Certificate

active

10930197

ABSTRACT:
Electrospray systems, electrospray structures, removable electrospray structures, methods of operating electrospray systems, and methods of fabricating electrospray systems, are disclosed.

REFERENCES:
patent: 3683212 (1972-08-01), Zoltan
patent: 3997113 (1976-12-01), Pennebaker, Jr.
patent: 5306412 (1994-04-01), Whitehouse et al.
patent: 5945678 (1999-08-01), Yanagisawa
patent: 6787763 (2004-09-01), De La Mora et al.
patent: 6797945 (2004-09-01), Berggren et al.
patent: 2001/0013579 (2001-08-01), Andrien et al.
patent: 2002/0168297 (2002-11-01), Shvets et al.
patent: 2005/0045833 (2005-03-01), Fischer et al.
patent: 2005/0153344 (2005-07-01), Diamond et al.
patent: 2005/0199824 (2005-09-01), Yamada et al.
Barber, et al.; Fast-atom-bombardment mass spectra of enkephalins; The Biochemical Society; 1981; vol. 197; pp. 401-404.
Barber, et al.; Fast atom Bombardment of Solids (F.A.B.): A New Ion Source For Mass Spectrometry; J.C.S. Chem. Comm., 1981; pp. 325-327.
Martin Bell; Taylor Cones and Electrosprays: a potential technique for creating new monodisperse colloids; The 1998 NSF REU summer program at Ohio State University Dept. of Physics; pp. 1-8.
Berggren, et al.; Single-Pulse Nanoelectrospray Ionization; Anal. Chem. 2002; vol. 74, No. 14; pp. 3443-3448.
Bings, et al.; Microfluidic Devices Connected to Fused-Silica Capillaries with Minimal Dead Volume; Anal. Chm.; 199; vol. 71; pp. 3292-3296.
Chen, et al.; A new method for significantly reducing drop radius without reducing nozzle radius in drop-on-demand drop production; Physics of Fluids; vol. 14, No. 1; Jan., 2002; pp. L1-L4.
Frank Vanhaecke; Detection by ICP-Mass Spectrometry; Handbook of Elemental Speciation; Techniques and Methodology; 2003; pp. 281-312.
Heij, et al.; Characterisation of a fL droplet generator for inhalation drug therapy; Sensors and Actuators 85; 2000; pp. 430-434.
Desai, et al.; A MEMS Electrospray Nozzle for Mass Spectroscopy; Transducers '97; 1997 International Conference on Solid-State Sensors and Actuators; Chicago, Jun. 16-19, 1997; pp. 927-930.
Dole, et al.; Molecular Beams of Macroions; The Journal of Chemical Physics; vol. 49, No. 5; Sep. 1, 1968; pp. 2240-2249.
Feng, et al.; A Simple Nanoelectrospray Arrangement With Controllable Flowrate for Mass Analysis of Submicroliter Protein Samples; J AM Soc Mass Spectrom 2000; vol. 11; pp. 94-99.
French, et al.; Monodisperse Dried Microparticulate Injector for Analytical Instrumentation; Anal. Chem. 1994; vol. 66, No. 5; pp. 685-691.
Simon J. Gaskell; Electrospray: Principles and Practice; Journal of Mass Spectrometry; vol. 32; 1997; pp. 677-688.
Hager, et al.; Behavior fo Microscopic Liquid Drolets near A Strong Electrostatic Field: Droplet Electrospray; Ana. Chem. 1994; vol. 66, No. 9; May 1, 1994; pp. 1593-1594.
Hager, et al.; Droplet Electrospray Mass Spectrometry; Anl. Chem. 1994; vol. 66, No. 22; Nov. 15, 1994; pp. 3944-3949.
He, et al.; 337 nm Matrix-assisted Laser Desorption/Ionization fo Single Aerosol Particles; J. Mass Spectrom.; 1999; vol. 34; p. 909-914.
Iribarne, et al.; On the evaporation of small ions from charged droplets; J. Chem. Phys., vol. 64, No. 6, Mar. 15, 1976; pp. 2287-2294.
De Juan et al.; Charge and Size Distributions of Electrospray Drops; Journal of Colliod and Interface Science; vol. 186; 1997; pp. 280-293.
Kirlew, et al.; An evaluation of ultrasonic nebulizers as interfaces for capillary electrophoresis of inorganic anions and cations with inductively coupled plasma mass spectrometric detection; Spectrochimica Acta Part B 53; 1998; pp. 221-237.
Li, et al.; Transport, Manipulation and Reaction of Biological Cells On-Chip Using Electrokinetic Effects; Anal. Chem; 1997; vol. 69, No. 8; Apr. 15, 1 997; pp. 1564-1568.
Li, et al.; Integration of Microfabricated Devices to Capillary Electrophoresis-Electrospray Mass Spectrometry Using a Low Dead Volume Connection: Application to Rapid Analyses of Proteolytic Digests; Anal. Chem. 1994; vol. 71, No. 15; Aug. 1, 1999; pp. 3036-3045.
Li, et al.; Separation and Identification of Peptides from Gel-Isolated Membrane Proteins Using a Microfabricated Device for Combined Capillary Electrophoresis/Nanoelectrospray Mass Spectrometry; Anal. Chem. 2000; vol. 72, No. 3, Feb. 1, 2000; pp. 599-609.
Licklider, et al.; A Micromachined Chip-Based Electrospray Source for Mass Spectrometry; Anal. Chm. 200; vol. 72, No. 2, Jan. 15, 2000; pp. 367-375.
Percin, et al.; Micromachined droplet ejector arrays; Review of Scientific Instruments; vol. 73, No. 12, Dec. 2002; pp. 4385-4389.
Percin, et al.; Micromachined droplet ejector arrays for controlled ink-jet printing and deposition; Review of Scientific Instruments; vol. 73, No. 5; May 2002; pp. 2193-2196.
Percin, et al.; Piezoelectrically actuated flextensional micromachined ultrasound tranducers; Ultrasonics 40; 2002; pp. 441-448.
Percin, et al.; Piezoelectric droplet ejector for ink-jet printing of fluids and solid particles; Review of Scientific Instruments; vol. 74, No. 2; Feb. 2003; pp. 1120-1127.
Ramsey, et al.; Generating Electrospray from Microchip DevicesUsing Electroosmotic Pumping; Anal. Chem. 1997; vol. 69, No. 6, Mar. 15, 1997; pp. 1174-1178.
Schultz, et al.; A Fully Integrated Monolithic Microchip Electrospray Device for Mass Spectrometry; Anal. Chem. 2000; vol. 72, No. 17, Sep. 1, 2000; pp. 4058-5063.
Gary L. Switzer; A versatile system for stable generation of uniform droplets; Review of Scientific Instruments; vol. 62, No. 11, Nov. 1999, pp. 2765-2771.
Wang, et al.; Polymer-Based Electrospray Chips for Mass Spectrometry; IEEE; 1999; pp. 523-528.
Wilm, et al.; Analytical Properties of the Nanoelectrospray Ion Source; Analytical Chemistry; vol. 68, No. 1; Jan. 1, 1996; pp. 1-8.

Affiliated with

Also associated with

Rating

Electrospray systems and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Electrospray systems and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Electrospray systems and methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3789743