Electrospray emitter for microfluidic channel

Details Electrospray emitter for microfluidic channel Electrospray emitter for microfluidic channel

2006-09-12

2006-09-12

Lee, John R. (Department: 2881)

Radiant energy

Ionic separation or analysis

With sample supply means

C210S656000, C210S748080

Reexamination Certificate

active

07105810

ABSTRACT:
An electrospray ionization device incorporates a shaped thin film with a microfluidic channel. The device may be interfaced to a time-of-flight mass spectrometer (TFOMS). In one embodiment, the shaped thin film has a polygonal-shaped or triangle-shaped thin polymer tip formed by lithography and etching. The microfluidic channel is approximately 20 micrometer wide and 10 micrometers deep, and embossed in a substrate using a silicon master. The shaped thin film is aligned with the channel and bonded between the channel substrate and a flat plate to create a microfluidic channel with a wicking tip protruding from the end of the channel. Application of a high voltage at one end of the channel creates an electrospray from the tip, which is provided to the TFOMS.

REFERENCES:
patent: 4443319 (1984-04-01), Chait et al.
patent: 4483885 (1984-11-01), Chait et al.
patent: 4963736 (1990-10-01), Douglas et al.
patent: 5296114 (1994-03-01), Manz
patent: RE34757 (1994-10-01), Smith et al.
patent: 5358618 (1994-10-01), Ewing et al.
patent: 5395975 (1995-02-01), Hail et al.
patent: 5423964 (1995-06-01), Smith et al.
patent: 5599432 (1997-02-01), Manz et al.
patent: 5624539 (1997-04-01), Ewing et al.
patent: 5705813 (1998-01-01), Apffel et al.
patent: 5716825 (1998-02-01), Hancock et al.
patent: 5800690 (1998-09-01), Chow et al.
patent: 5833861 (1998-11-01), Afeyan et al.
patent: 5856671 (1999-01-01), Henion et al.
patent: 5858188 (1999-01-01), Soane et al.
patent: 5858195 (1999-01-01), Ramsey
patent: 5866345 (1999-02-01), Wilding et al.
patent: 5872010 (1999-02-01), Karger et al.
patent: 5885470 (1999-03-01), Parce et al.
patent: 5917184 (1999-06-01), Carson et al.
patent: 5935401 (1999-08-01), Amigo
patent: 5958202 (1999-09-01), Regnier et al.
patent: 5965001 (1999-10-01), Chow et al.
patent: 5969353 (1999-10-01), Hsieh
patent: 5993633 (1999-11-01), Smith et al.
patent: 5994696 (1999-11-01), Tai et al.
patent: 6001229 (1999-12-01), Ramsey
patent: 6010607 (2000-01-01), Ramsey
patent: 6010608 (2000-01-01), Ramsey
patent: 6012902 (2000-01-01), Parce
patent: 6033546 (2000-03-01), Ramsey
patent: 6033628 (2000-03-01), Kaltenbach et al.
patent: 6054034 (2000-04-01), Soane et al.
patent: 6056860 (2000-05-01), Amigo et al.
patent: 6068749 (2000-05-01), Karger et al.
patent: 6086243 (2000-07-01), Paul et al.
patent: 6110343 (2000-08-01), Ramsey et al.
patent: 6123798 (2000-09-01), Gandhi et al.
patent: 6139734 (2000-10-01), Settlage et al.
patent: 6149870 (2000-11-01), Parce et al.
patent: 6156181 (2000-12-01), Parce et al.
patent: 6159739 (2000-12-01), Weigl et al.
patent: 6176962 (2001-01-01), Soane et al.
patent: 6187190 (2001-02-01), Smith et al.
patent: 6231737 (2001-05-01), Ramsey et al.
patent: 6238538 (2001-05-01), Parce et al.
patent: 6240790 (2001-06-01), Swedberg et al.
patent: 6245227 (2001-06-01), Moon et al.
patent: 6277641 (2001-08-01), Yager
patent: 6280589 (2001-08-01), Manz et al.
patent: 6284113 (2001-09-01), Bjornson et al.
patent: 6284115 (2001-09-01), Apffel
patent: 6297499 (2001-10-01), Fenn
patent: 6318970 (2001-11-01), Backhouse
patent: 6322682 (2001-11-01), Arvidsson et al.
patent: 6326616 (2001-12-01), Andrien, Jr. et al.
patent: 6337740 (2002-01-01), Parce
patent: 6342142 (2002-01-01), Ramsey
patent: 6368562 (2002-04-01), Yao
patent: 6375817 (2002-04-01), Taylor et al.
patent: 6394942 (2002-05-01), Moon et al.
patent: 6409900 (2002-06-01), Parce et al.
patent: 6413401 (2002-07-01), Chow et al.
patent: 6416642 (2002-07-01), Alajoki et al.
patent: 6417510 (2002-07-01), Moon et al.
patent: 6423198 (2002-07-01), Manz et al.
patent: 6432311 (2002-08-01), Moon et al.
patent: 6444461 (2002-09-01), Knapp et al.
patent: 6450047 (2002-09-01), Swedberg et al.
patent: 6450189 (2002-09-01), Ganan-Calvo
patent: 6454924 (2002-09-01), Jedrzejewski et al.
patent: 6454938 (2002-09-01), Moon et al.
patent: 6459080 (2002-10-01), Yin et al.
patent: 6461516 (2002-10-01), Moon et al.
patent: 6462337 (2002-10-01), Li et al.
patent: 6464866 (2002-10-01), Moon et al.
patent: 6465776 (2002-10-01), Moini et al.
patent: 6475363 (2002-11-01), Ramsey
patent: 6475441 (2002-11-01), Parce et al.
patent: 6481648 (2002-11-01), Zimmermann
patent: 6491804 (2002-12-01), Manz et al.
patent: 6495016 (2002-12-01), Nawracala
patent: 6500323 (2002-12-01), Chow et al.
patent: 6514399 (2003-02-01), Parce et al.
patent: 6517234 (2003-02-01), Kopf-Sill et al.
patent: 6524456 (2003-02-01), Ramsey et al.
patent: 6541768 (2003-04-01), Andrien, Jr. et al.
patent: 6555067 (2003-04-01), Gandhi et al.
patent: 6569324 (2003-05-01), Moon et al.
patent: 6576896 (2003-06-01), Figeys et al.
patent: 6596988 (2003-07-01), Corso et al.
patent: 6602472 (2003-08-01), Zimmermann et al.
patent: 6605472 (2003-08-01), Skinner et al.
patent: 6607644 (2003-08-01), Apffel, Jr.
patent: 6621076 (2003-09-01), van de Goor et al.
patent: 6627076 (2003-09-01), Griffiths
patent: 6627882 (2003-09-01), Schultz et al.
patent: 6632655 (2003-10-01), Mehta et al.
patent: 6653625 (2003-11-01), Andersson et al.
patent: 6681788 (2004-01-01), Parce et al.
patent: 6695009 (2004-02-01), Chien et al.
patent: 6709559 (2004-03-01), Sundberg et al.
patent: 6733645 (2004-05-01), Chow
patent: 6744046 (2004-06-01), Valaskovic et al.
patent: 6803568 (2004-10-01), Bousse et al.
patent: 6814859 (2004-11-01), Koehler et al.
patent: 6827095 (2004-12-01), O'Connor et al.
patent: 2001/0037979 (2001-11-01), Monn et al.
patent: 2002/0036140 (2002-03-01), Manz et al.
patent: 2002/0041827 (2002-04-01), Yager et al.
patent: 2002/0100714 (2002-08-01), Staats
patent: 2002/0110902 (2002-08-01), Prosser et al.
patent: 2002/0117517 (2002-08-01), Unger et al.
patent: 2002/0121487 (2002-09-01), Robotti et al.
patent: 2002/0123153 (2002-09-01), Moon et al.
patent: 2002/0139931 (2002-10-01), Yin et al.
patent: 2002/0158195 (2002-10-01), Anderson et al.
patent: 2002/0170825 (2002-11-01), Lee et al.
patent: 2002/0182649 (2002-12-01), Weinberger et al.
patent: 2003/0000835 (2003-01-01), Witt et al.
patent: 2003/0017609 (2003-01-01), Yin et al.
patent: 2003/0026740 (2003-02-01), Staats
patent: 2003/0029724 (2003-02-01), Derand et al.
patent: 2003/0047680 (2003-03-01), Figeys et al.
patent: 2003/0066959 (2003-04-01), Andersson et al.
patent: 2003/0073260 (2003-04-01), Corso
patent: 2003/0082080 (2003-05-01), Zimmermann et al.
patent: 2003/0089605 (2003-05-01), Timperman
patent: 2003/0089606 (2003-05-01), Parce et al.
patent: 2003/0106799 (2003-06-01), Covington et al.
patent: 2003/0111599 (2003-06-01), Staats
patent: 2003/0146757 (2003-08-01), Aguero et al.
patent: 2003/0148922 (2003-08-01), Knapp et al.
patent: 2003/0153007 (2003-08-01), Chen et al.
patent: 2003/0180965 (2003-09-01), Yobas et al.
patent: 2003/0213918 (2003-11-01), Kameoka et al.
patent: 2003/0215855 (2003-11-01), Dubrow et al.
patent: 2004/0053333 (2004-03-01), Hitt et al.
patent: 2004/0075050 (2004-04-01), Rossier et al.
patent: 2004/0096960 (2004-05-01), Mehta et al.
patent: 2004/0159783 (2004-08-01), Gavin et al.
patent: 2005/0123688 (2005-06-01), Craighead et al.
patent: 2005/0178960 (2005-08-01), Kameoka et al.
patent: 0653631 (1995-05-01), None
patent: 2379554 (2003-03-01), None
patent: WO-9111015 (1991-07-01), None
patent: WO-9604547 (1996-02-01), None
patent: WO-9636425 (1996-11-01), None
patent: WO 0041214 (2000-07-01), None
patent: WO-0062039 (2000-10-01), None
patent: WO-02/30486 (2002-04-01), None
patent: WO-02030486 (2002-04-01), None
patent: WO-0245865 (2002-06-01), None
patent: WO-0247913 (2002-06-01), None
patent: WO-02055990 (2002-07-01), None
patent: WO-02080222 (2002-10-01), None
patent: WO-03004160 (2003-01-01), None
patent: WO-03019172 (2003-03-01), None
patent: WO-03054488 (2003-07-01), None
patent: WO-2004044574 (2004-05-01), None
patent: WO-2004051697 (2004-06-01), None
patent: WO-2004062801 (2004-07-01), None
patent: WO-2004067162 (2004-08-01), None
patent: WO-2004070051 (2004-08-01), None
Bings, Nicolas H., et al., “Microfluidic Devices Connected to Fused-Silica Capillaries with Minimal Dead Volume”,Anal. Chem., 71,(1999),3292-3296
Chan, Jason H., et al., “Microfabricated Polymer D

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