Electroresponsive hydrogel and physiologically active substance

Details Electroresponsive hydrogel and physiologically active substance Electroresponsive hydrogel and physiologically active substance

1990-07-23

1992-10-06

Rosenbaum, C. Fred

Surgery

Controlled release therapeutic device or system

604 20, 604 65, A61K 922

Patent

active

051527588

ABSTRACT:
An electroresponsive hydrogel produced by alkali hydrolysis of a copolymer comprising N-isopropylacrylamide, an ionic monomer and a crosslinking agent; and a physiologically active substance release control system comprising a biosensor, an amplifier and an electroresponsive hydrogel containing physiologically active substance are disclosed. The hydrogel of the present invention is capable of releasing a physiologically active substance alone in an amount corresponding to the applied voltage with excellent reproducibility by contracting and reswelling in good response to the loading and unloading of an external stimulation voltage, it can be advantageously used in a physiologically active substance release control system capable of releasing an essential physiologically active substance in a necessary amount according to changes in physiological conditions. Also, the physiologically active substance release control system of the present invention using this hydrogel is useful for the treatment of various diseases including diabetes mellitus.

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