Electroporetic gene and drug therapy

Details Electroporetic gene and drug therapy Electroporetic gene and drug therapy

1994-10-25

2000-10-17

Weiss, John G.

Surgery

Controlled release therapeutic device or system

6048911, 604 20, 604500, 604507, 607 3, 607 68, 607 72, 607 74, 607115, 4351736, 204451, 204601, A61K 922, A61N 130, A61N 118, A61M 3100

Patent

active

061324191

ABSTRACT:
A method and apparatus are provided for introducing molecules such as genes and pharmaceutical compounds into living blood cells of a patient for therapeutic purposes. A device is placed into contact with the body of the patient for generating an electric field at a preselected location within a selected blood vessel. Preselected molecules are infused into the selected blood vessel. Simultaneously an electric signal is applied to the applied device to repeatedly subject a quantity of blood flowing within the selected blood vessel past the preselected location to electric fields of a predetermined amplitude and duration. The parameters of the electric fields are precisely controlled in order to make the walls of preselected cells in the blood transiently permeable to permit the molecules to enter said preselected cells without killing said cells. The device can include either an induction coil that is placed into contact with the body over a blood vessel, or alternatively, an induction coil that surrounds the blood vessel. The electric signal is supplied by a power pack and the preselected molecules are infused with a supply pump.

REFERENCES:
patent: 2320462 (1943-06-01), Nawells
patent: 3978864 (1976-09-01), Smith et al.
patent: 4440178 (1984-04-01), Bussard et al.
patent: 4639244 (1987-01-01), Rizk et al.
patent: 4690130 (1987-09-01), Mirell
patent: 4801459 (1989-01-01), Liburdy
patent: 4842598 (1989-06-01), Tran
patent: 4906576 (1990-03-01), Marshall, III
patent: 4936317 (1990-06-01), MacGregor
patent: 4970154 (1990-11-01), Chang
patent: 5016615 (1991-05-01), Driller et al.
patent: 5019034 (1991-05-01), Weaver et al.
patent: 5042975 (1991-08-01), Chien et al.
patent: 5087243 (1992-02-01), Avitall
patent: 5098843 (1992-03-01), Calvin
patent: 5128257 (1992-07-01), Baer
patent: 5183456 (1993-02-01), Liboff et al.
patent: 5224922 (1993-07-01), Kurtz
patent: 5236413 (1993-08-01), Feiring
patent: 5246437 (1993-09-01), Abela
patent: 5273525 (1993-12-01), Hofmann
patent: 5286254 (1994-02-01), Shapland et al.
patent: 5290409 (1994-03-01), Liboff et al.
patent: 5304120 (1994-04-01), Crandell et al.
patent: 5318514 (1994-06-01), Hofmann
patent: 5389069 (1995-02-01), Weaver
patent: 5419763 (1995-05-01), Hildebrand
patent: 5439440 (1995-08-01), Hofmann
patent: 5501662 (1996-03-01), Hofmann
Engineering Circuit Analysis, 3rd Ed. pp. 136-137, 526-529.
Modern Dictionary of Electronics, p. 156, 242.

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