Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Patent
1993-04-01
1995-08-08
Rosenbaum, C. Fred
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
604 49, A61N 130
Patent
active
054394406
ABSTRACT:
A method and apparatus are provided for introducing macromolecules such as genes and pharmacological compounds into cells of a patient for therapeutic purposes. An apparatus for the therapeutic application of electroporation to a portion of the anatomy of a patient, includes adjustably spaced electrodes for generating an electric field at a preselected location within a body of a patient, a sensor for generating a distance signal proportionate to the space between the electrodes, and an electrical signal generator responsive to the distance signal for applying an electric signal to the electrodes for causing the repeated generation of electric fields of a predetermined amplitude and duration forcing the walls of preselected cells in the body portion to be transiently permeable for permitting the macromolecules to enter the preselected cells.
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patent: 4784737 (1988-11-01), Ray et al.
patent: 4955378 (1990-09-01), Grasso
patent: 5019034 (1991-05-01), Weaver et al.
patent: 5128257 (1992-07-01), Baer
patent: 5273525 (1993-12-01), Hofmann
Bockelman Mark
Genetronics Inc.
Rosenbaum C. Fred
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