Electroporation microneedle and methods for its use

Details Electroporation microneedle and methods for its use Electroporation microneedle and methods for its use

2006-10-24

2006-10-24

Thanh, LoAn H. (Department: 3763)

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

C604S272000

Reexamination Certificate

active

07127284

ABSTRACT:
Electroporation of cells in target tissues is performed using microneedles having integral electrode structures. In a first embodiment, a pair of electrode structures are disposed on opposite sides of a substance delivery opening on a needle or other tissue-penetrating shaft. In a second embodiment, a first electrode structure is disposed on the needle and a second electrode structure is disposed on an attached base. The electrode structures are spaced closely together and relatively low voltages are applied to achieve electroporation-enhanced substance delivery.

REFERENCES:
patent: 5273525 (1993-12-01), Hofmann
patent: 5389069 (1995-02-01), Weaver
patent: 5588961 (1996-12-01), Leone et al.
patent: 5591139 (1997-01-01), Lin et al.
patent: 5697901 (1997-12-01), Eriksson
patent: 5702359 (1997-12-01), Hofmann et al.
patent: 5807395 (1998-09-01), Mulier et al.
patent: 5823993 (1998-10-01), Lemelson
patent: 5855801 (1999-01-01), Lin et al.
patent: 5869326 (1999-02-01), Hofmann
patent: 5928207 (1999-07-01), Pisano et al.
patent: 5964727 (1999-10-01), Edwards et al.
patent: 6014584 (2000-01-01), Hofmann et al.
patent: 6077257 (2000-06-01), Edwards et al.
patent: 6090790 (2000-07-01), Eriksson
patent: 6102887 (2000-08-01), Altman
patent: 6104952 (2000-08-01), Tu et al.
patent: 6181964 (2001-01-01), Hofmann et al.
patent: 6233482 (2001-05-01), Hofmann et al.
patent: 6241701 (2001-06-01), Hofmann
patent: 6312612 (2001-11-01), Sherman et al.
patent: 6331266 (2001-12-01), Powell et al.
patent: 6334856 (2002-01-01), Allen et al.
Bailey, “Local drug delivery during percutaneous coronary intervention” Current Interventional Cardiology Reports (2000) 2:349-357.
Chan et al., “Update on pharmacology for restenosis” Current Interventional Cardioogy Reports (2001) 3:149-155.
Stupar et al., “Silicon, parylene, and silicon/parylene micro-needles for strength and toughness” Transducers '01, 11th International Conference on Solid-State Sensors and Actuators, Munich, Germany, (Jun. 10-14, 2001) 4 pages total.
Varenne et al., “Gene therapy for coronary restenosis: A promising strategy for the new millennuim?” Current Interventional Cardiology Reports (2000) 2:309-315.
Product Brochure for “The Infiltrator®” Device Specifications, Interventional Technologies, Inc., 3574 Ruffin Road, San Diego, CA 92123, 4 pages total.

Affiliated with

Also associated with

Rating

Electroporation microneedle and methods for its use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Electroporation microneedle and methods for its use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Electroporation microneedle and methods for its use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3637439