Electroporation device and method, delivering a modulated...

Details Electroporation device and method, delivering a modulated... Electroporation device and method, delivering a modulated...

2007-12-11

2007-12-11

Redding, David (Department: 1744)

Chemistry: molecular biology and microbiology

Apparatus

Mutation or genetic engineering apparatus

C435S173500, C435S173600

Reexamination Certificate

active

10274738

ABSTRACT:
An electroporation device having a signal generating circuit (3) connectable at the output to electrodes (5) fittable to a substrate (35) having cells. The electrodes (5) produce an electric field which induces permeabilization of the cell membranes to facilitate introduction of substances into the cells. The amplitude of the signal (12) applied to the electrodes is closed-loop controlled on the basis of the impedance (Z(ω)) of the substrate, so as to regulate the amplitude of the signal following a reduction in impedance caused by permeabilization of the cell membranes.

REFERENCES:
patent: 5019034 (1991-05-01), Weaver et al.
patent: 5134070 (1992-07-01), Casnig
patent: WO 96/39531 (1996-12-01), None
patent: WO 00/20554 (2000-04-01), None
patent: WO 01/07583 (2001-02-01), None
patent: WO 01/07584 (2001-02-01), None

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