Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Cell membrane or cell surface is target
Reexamination Certificate
2003-06-10
2009-12-01
Beisner, William H (Department: 1797)
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Cell membrane or cell surface is target
C435S173400, C435S173500, C435S285200, C435S461000, C204S403010, C205S777500
Reexamination Certificate
active
07625729
ABSTRACT:
Electro-poration device for the permeabilization of cells contained in a substrate comprising a signal generator for generating a stimulating signal applied by means of electrodes to the substrate wherein an electric field permeabilizing the cells membranes is induced. The device calculates and monitors the instantaneous value or the ratio GT between the current flowing through the substrate and the voltage of the stimulating signal applied to the substrate; in particular, the stimulating signal is applied in a modified manner according to the shape of an initial portion of the waveform of a curve CGT representing the value of ratio GT in successive instants after the application of the stimulating signal. The system will achieve permeabilization of cells in substrate with no or minimum damage, allowing to introduce or to extract molecules in or from the electropermeabilized living cells.
REFERENCES:
patent: 6653091 (2003-11-01), Dunn et al.
patent: 01 07583 (2001-02-01), None
patent: 01 07584 (2001-02-01), None
patent: 01 07585 (2001-02-01), None
patent: 01 81533 (2001-11-01), None
International Search Report for International Application No. PCT/EP03/05993 dated Oct. 30, 2003.
Miklavcic Damijan
Mir Lluis
Beisner William H
Hobbs Michael
IGEA S.r.l.
Ostrolenk Faber LLP
LandOfFree
Electroporation device does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Electroporation device, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Electroporation device will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4073197