Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Reexamination Certificate
2003-08-25
2010-06-22
Lucchesi, Nicholas D (Department: 3763)
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
Reexamination Certificate
active
07742809
ABSTRACT:
In general, the invention is directed to techniques for delivering macromolecules to a tissue site via electroporation. Particularly, a catheter detects contact between a distal end of the catheter and a target tissue site via a sensing electrode at the distal end of the catheter. The catheter delivers a fluid containing macromolecules to the tissue site upon detecting contact between the tissue site and the catheter. Concurrently or soon after delivery of the fluid, an electrical stimulus is applied to the tissue site. The electrical stimulus can be applied by the catheter or directly from a power supply, such as an implanted pulse generator. The electrical stimulus causes membranes of cells within the tissue site to destabilize, in turn, forming pores through which the macromolecules migrate into the cells of the tissue site.
REFERENCES:
patent: 5087243 (1992-02-01), Avitall
patent: 5147332 (1992-09-01), Moorehead
patent: 5389069 (1995-02-01), Weaver
patent: 5403311 (1995-04-01), Abele et al.
patent: 5499971 (1996-03-01), Shapland et al.
patent: 5634899 (1997-06-01), Shapland et al.
patent: 5807306 (1998-09-01), Shapland et al.
patent: 5807395 (1998-09-01), Mulier et al.
patent: 5833715 (1998-11-01), Vachon et al.
patent: 5865787 (1999-02-01), Shapland et al.
patent: 5925066 (1999-07-01), Kroll et al.
patent: 6009347 (1999-12-01), Hofmann
patent: 6090619 (2000-07-01), Weissig et al.
patent: 6120493 (2000-09-01), Hofmann
patent: 6208893 (2001-03-01), Hofmann
patent: 6309370 (2001-10-01), Haim et al.
patent: 6347247 (2002-02-01), Dev et al.
patent: 6361522 (2002-03-01), Scheiner et al.
patent: 6516223 (2003-02-01), Hofmann
patent: 6835193 (2004-12-01), Epstein et al.
patent: 2002/0099328 (2002-07-01), Scheiner et al.
patent: 2002/0183738 (2002-12-01), Chee et al.
patent: 2003/0074024 (2003-04-01), Stokes et al.
patent: 2 365 351 (1978-04-01), None
Krassowska, W., “Effects of Electroporation on Transmembrane Potential Induced by Defibrillation Shocks”,PACE, vol. 18, Sep. 1995, Part I, pp. 1644-1660.
Tovar, O., et al., “Electroporation and Recovery of Cardiac Cell Membrane with Retangular Voltage Pulses”,The American Physiological Society, 263:H1128-H1136 (1992).
Harrison, R.L., et al. “Electrophoration-Mediated Gener Transfer in Cardiac Tissue”,FESB Letters, 435:1-5 (1998).
Casas-Bejar Jesus W.
Cross Daisy P.
Padua Rodolfo A.
Sigg Daniel C.
Koharski Christopher D
Lucchesi Nicholas D
Medtronic Inc.
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