Electroporation catheter with sensing capabilities

Details Electroporation catheter with sensing capabilities Electroporation catheter with sensing capabilities

2003-08-25

2010-06-22

Lucchesi, Nicholas D (Department: 3763)

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

Reexamination Certificate

active

07742809

ABSTRACT:
In general, the invention is directed to techniques for delivering macromolecules to a tissue site via electroporation. Particularly, a catheter detects contact between a distal end of the catheter and a target tissue site via a sensing electrode at the distal end of the catheter. The catheter delivers a fluid containing macromolecules to the tissue site upon detecting contact between the tissue site and the catheter. Concurrently or soon after delivery of the fluid, an electrical stimulus is applied to the tissue site. The electrical stimulus can be applied by the catheter or directly from a power supply, such as an implanted pulse generator. The electrical stimulus causes membranes of cells within the tissue site to destabilize, in turn, forming pores through which the macromolecules migrate into the cells of the tissue site.

REFERENCES:
patent: 5087243 (1992-02-01), Avitall
patent: 5147332 (1992-09-01), Moorehead
patent: 5389069 (1995-02-01), Weaver
patent: 5403311 (1995-04-01), Abele et al.
patent: 5499971 (1996-03-01), Shapland et al.
patent: 5634899 (1997-06-01), Shapland et al.
patent: 5807306 (1998-09-01), Shapland et al.
patent: 5807395 (1998-09-01), Mulier et al.
patent: 5833715 (1998-11-01), Vachon et al.
patent: 5865787 (1999-02-01), Shapland et al.
patent: 5925066 (1999-07-01), Kroll et al.
patent: 6009347 (1999-12-01), Hofmann
patent: 6090619 (2000-07-01), Weissig et al.
patent: 6120493 (2000-09-01), Hofmann
patent: 6208893 (2001-03-01), Hofmann
patent: 6309370 (2001-10-01), Haim et al.
patent: 6347247 (2002-02-01), Dev et al.
patent: 6361522 (2002-03-01), Scheiner et al.
patent: 6516223 (2003-02-01), Hofmann
patent: 6835193 (2004-12-01), Epstein et al.
patent: 2002/0099328 (2002-07-01), Scheiner et al.
patent: 2002/0183738 (2002-12-01), Chee et al.
patent: 2003/0074024 (2003-04-01), Stokes et al.
patent: 2 365 351 (1978-04-01), None
Krassowska, W., “Effects of Electroporation on Transmembrane Potential Induced by Defibrillation Shocks”,PACE, vol. 18, Sep. 1995, Part I, pp. 1644-1660.
Tovar, O., et al., “Electroporation and Recovery of Cardiac Cell Membrane with Retangular Voltage Pulses”,The American Physiological Society, 263:H1128-H1136 (1992).
Harrison, R.L., et al. “Electrophoration-Mediated Gener Transfer in Cardiac Tissue”,FESB Letters, 435:1-5 (1998).

Affiliated with

Also associated with

Rating

Electroporation catheter with sensing capabilities does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Electroporation catheter with sensing capabilities, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Electroporation catheter with sensing capabilities will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4250192