Electroporation and iontophoresis catheter with porous balloon

Details Electroporation and iontophoresis catheter with porous balloon Electroporation and iontophoresis catheter with porous balloon

1996-10-10

1998-01-06

Bockelman, Mark

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

604 96, A61N 130

Patent

active

057049084

ABSTRACT:
An electroporation apparatus for introducing molecules into cells at a selected location within a cavity in the body of a patient includes an elongated catheter having a proximal end and a distal end and a guide wire extending from the proximal end to the distal end, an inflatable balloon carried by the distal end, the balloon having an inner inflatable bladder and an outer perforated bladder defining a chamber between the two bladders, a first electrode on an outer surface of the outer perforated bladder, a second electrode spaced from the first electrode, a remote electrode, a lumen for delivering a predetermined quantity of a fluid medium carrying preselected molecules into the chamber to be infused into the body cavity at the predetermined location; and a source of power for applying a voltage pulse between selected pairs of the electrodes for transport of the molecules by iontophoresis and/or repeatedly generating electric fields of a predetermined amplitude and duration inducing the walls of a plurality of cells at the predetermined location to be transiently permeable to enable the molecules to enter the cells.

REFERENCES:
patent: 5286254 (1994-02-01), Shapland et al.
patent: 5304120 (1994-04-01), Crandell et al.
patent: 5505700 (1996-04-01), Leone et al.
patent: 5507724 (1996-04-01), Hofmann et al.

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