Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Reexamination Certificate
2007-07-23
2010-02-23
Lucchesi, Nicholas D (Department: 3763)
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
Reexamination Certificate
active
07668592
ABSTRACT:
The electroporation system and method combine pulses having different characteristics for delivering molecules to cells in vivo. The pulses include a high-intensity pulse for inducing electroporation and a low-intensity pulse to induce electrophoretic molecule movement within an interstitial space, molecule adherence to a cell membrane, and electrophoretic movement of the molecule through the permeabilized membrane. The use of a high-intensity and a low-intensity pulse achieves improved delivery; reduction of intensity and/or duration of pulses for inducing electroporation; and decreased muscle stimulation, tissue damage, and patient discomfort.
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Gilbert Richard
Heller Loree C.
Heller Richard
Jaroszeski Mark J.
Lucas Melinda L.
Lucchesi Nicholas D
Sauter Molly L.
Smith & Hopen , P.A.
Stigell Theodore J
University of South Florida
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