Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-02-03
1997-05-27
Marschel, Ardin H.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 18, 4351731, 4352831, 4352851, 4352871, 4352872, 4352891, 435810, 422 681, 436501, 536 221, 536 253, 536 254, 935 77, 935 78, 935 88, C12Q 168
Patent
active
056331290
ABSTRACT:
The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique melting temperature contiguous with a melting domain of higher thermal stability.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 5045450 (1991-09-01), Thilly et al.
patent: 5087559 (1992-02-01), Smith et al.
patent: 5112460 (1992-05-01), Karger et al.
Cohen et al. (1988) Proceedings of the National Acad. of Sci. (USA), vol. 85, pp. 9660-9663.
Heiger et al. (1990) J. of Chromatography, vol. 516, pp. 33-48.
Ganzler et al. (1992) Anal. Chem., vol. 64, pp. 2665-2671.
Myers et al. (1985) Nature, vol. 313, pp. 495-498.
Cotton, R. G. H., "Current Methods of Mutation Detection," Mutation Research, 285:125-144 (1993).
Hovig, E. et al., "Constant Denaturant Gel Electrophoresis, a Modification of Denaturing Gradient Gel Electrophoresis, in Mutation Detection," Mutation Research, 262:63-71 (1991).
Castro A. et al., "Fluorescence Detection and Size Measurement of Single DNA Molecules," Anal. Chem., 65:849-852 (1993).
Pariat, Y.F. et al., "Separation of DNA Fragments by Capillary Electrophoresis Using Replaceable Linear Polyacrylamide Matrices," J. of Chromatography A., 652:57-66 (1993).
Ruiz-Martinez, M.C., et al., "DNA Sequencing by Capillary Electrophoresis with Replaceable Linear Polyacrylamide and Laser-Induced Fluorescence Detection," Anal. Chem., 65:2851-2858 (1993).
Harris, C.C., "p. 53: At the Crossroads of Molecular Carcinogenesis and Risk Assessment," Science, 262:1980-1981 (1993.
Cariello, N.F., et al., "Resolution of a Missense Mutant in Human Genomic DNA by Denaturing Gradient Gel Electrophoresis and Direct Sequencing Using In Vitro DNA Amplification: HPRT.sub.Munich," Am. J. Hum. Genet., 42:726-734 (1988).
Karger, B.L., et al., "High-Performance Capillary Electrophoresis in the Biological Sciences," J. of Chrom., 492:585-614 (1989).
Cohen, A.S. et al., "Separation and Analysis of DNA Sequence Reaction Products by Capillary Gel Electrophoresis," J. of Chrom. 516:49-60 (1990).
Kasper, T.J., et al., "Separation and Detection of DNA by Capillary Electrophoresis," J. Chromatography, 458:303-312 (1988).
Kuhr, W.G. and Yeung, E.S., "Optimization of Sensitivity and Separation in Capillary Zone Electrophoresis with Indirect Fluorescence Detection," Anal. Chem., 60:2642-2646 (1988).
Fischer, S.G. and Lerman, L.S., "DNA Fragments Differing by Single Base-Pair Substitutions are Separated in Denaturing Gradient Gels: Corresponding with Melting Theory," Proc. Natl. Acad. Sci. USA, 80:1579-1583 (1983).
Wallingford, R.A. and Ewing A.G., "Capillary Zone Electrophoresis with Electrochemical Detection," Anal. Chem., 59:1762-1766 (1987).
Gordon, M.J., et al., "Capillary Electrophoresis," Science, 242:224-228 (1988).
Smith, R.D., et al., "Improved Electrospray Ionization Interface for Capillary Zone Electrophoresis-Mass Spectrometry," Anal. Chelm., 60:1948-1952.
Lee, E.D., et al., "On-Line Capillary Zone Electrophoresis-Ion Spray Tandem Mass Spectrometry for the Determination of Dynorphins," J. Chromatography, 458:313-321 (1988).
Porteous, D.J., "Rapid and Quantitative Detection of Unique Sequence Donor DNA in Extracts of Cultured Mammalian Cells: An Aid to Chromosome Mapping," Som. Cell and Mol. Genet., 11(5):445-454 (1985).
Lerman, L.S., and Silverstein, K., "Computational Stimulation of DNA Melting and Its Application to Denaturing Gradient Gel Electrophoresis," Methods in Enzymology, 155:482-501 (1987).
Cohen, A.S., "Capillary Gel Electrophoresis of Biopolymers," Friends in Analy. Chem., 12(5):195-202 (1993).
Cohen Aharon S.
Foret Frantisek
Giese Roger W.
Karger Barry L.
Khrapko Konstaintin
Marschel Ardin H.
Massachusetts Institute of Technology
Northeastern University
LandOfFree
Electrophoretic detection and separation of mutant DNA using rep does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Electrophoretic detection and separation of mutant DNA using rep, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Electrophoretic detection and separation of mutant DNA using rep will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2328231