Electrophoresis-mass spectrometry probe

Details Electrophoresis-mass spectrometry probe Electrophoresis-mass spectrometry probe

1986-09-15

1987-11-10

Niebling, John F.

Chemistry: electrical and wave energy

Apparatus

Coating, forming or etching by sputtering

2041801, 436173, 250288, G01N 2400, G01N 2404, G01N 2726, H01J 4900

Patent

active

047056169

ABSTRACT:
The invention involves a new technique for the separation of complex mixtures of chemicals, which utilizes a unique interface probe for conventional mass spectrometers which allows the electrophoretically separated compounds to be analyzed in real-time by a mass spectrometer. This new chemical analysis interface, which couples electrophoresis with mass spectrometry, allows complex mixtures to be analyzed very rapidly, with much greater specificity, and with greater sensitivity. The interface or probe provides a means whereby large and/or polar molecules in complex mixtures to be completely characterized. The preferred embodiment of the probe utilizes a double capillary tip which allows the probe tip to be continually wetted by the buffer, which provides for increased heat dissipation, and results in a continually operating interface which is more durable and electronically stable than the illustrated single capillary tip probe interface.

REFERENCES:
Jose A. Olivares et al., "On-Line Mass Spectrometric Detection for Capillary Zone Electrophoresis" Analytical Chemistry, vol. 59, No. 8, Apr. 15, 1987.

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