Electrophilic polyethylene oxides for the modification of polysa

Stock material or miscellaneous articles – Composite – Of silicon containing

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525 541, 525 542, 525 5421, 525403, 525408, 427452, 427 23, 427 231, 427200, 427207, 530350, 530362, 530363, 530380, 530381, 530405, 530406, 530345, 536 21, 536 291, C07K 100, C07K 1400, C07K 1600

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056502346

ABSTRACT:
Several poly(ethylene glycol) mixed carbonates and their preparation are closed. These carbonates are synthesized by conversion of polyethylene glycol first to the chloroformate then by reaction with the hydroxyl group of N-hydroxybenzotriazole or 2-hydroxypyrimidine or N-hydroxy-2-pyrrolidinone. These mixed carbonate analogs smoothly react with amino groups in aminoglycans and protein and amino containing surfaces to form stable, hydrolysis resistant carbamate linkages.

REFERENCES:
patent: 5122614 (1992-06-01), Zalipsky
patent: 5321095 (1994-06-01), Greenwald
patent: 5324844 (1994-06-01), Zalipsky
patent: 5349001 (1994-09-01), Greenwald et al.
patent: 5510418 (1996-04-01), Rhee et al.

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