Electron-deficient nitrogen heterocycle-substituted...

Details Electron-deficient nitrogen heterocycle-substituted... Electron-deficient nitrogen heterocycle-substituted...

2007-05-29

2007-05-29

Ceperley, Mary E. (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C436S546000, C436S800000, C530S402000, C536S024300, C544S235000, C544S238000, C544S283000, C544S333000, C544S353000, C544S405000, C546S119000, C546S144000, C546S173000, C546S283100, C548S146000, C548S159000, C548S215000, C548S217000, C548S250000, C548S256000, C548S266200, C548S305100, C548S311400, C548S364400

Reissue Patent

active

10819078

ABSTRACT:
The invention provides compositions electron-deficient nitrogen heterocycle-substituted fluorescein dyes and methods in which the dyes are conjugated to substrates and used as detection labels in molecular biology experiments. The electron-deficient nitrogen heterocycles include pyridine, quinoline, pyrazine, and the like. Substrates include polynucleotides, nucleosides, nucleotides, peptides, proteins, carbohydrates, and ligands.

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R. M. Acheson, “Heterocyclic Analogues of Benzene with One Heteroatom,” An Introduction to the Chemistry of Heterocyclic Compounds, second edition, pp. 188-199.

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