Electricity: measuring and testing – Particle precession resonance
Reexamination Certificate
1998-10-20
2001-07-03
Patidar, Jay (Department: 2862)
Electricity: measuring and testing
Particle precession resonance
C324S309000
Reexamination Certificate
active
06255816
ABSTRACT:
TECHNICAL FIELD OF THE INVENTION
The present invention is in the field of magnetic resonance spectroscopy and imaging.
BACKGROUND OF THE INVENTION
This invention relates to magnetic resonance apparatus useful in nuclear magnetic resonance (NMR), magnetic resonance imaging (MRI) and electron spin resonance (ESR) devices. More specifically, this invention relates to electromagnetic frequency resonators useful in those apparatus for transmitting and/or receiving RF signals.
In the past, the NMR and ESR phenomenon have been utilized by structural chemists and physicists to study, in vitro, the molecular structure of atoms and molecules. Typically, NMR and ESR spectrometers utilized for this purpose were designed to accommodate relatively small samples of the substance to be studied.
More recently, however, NMR has been developed into an imaging modality utilized to obtain images of anatomical features of live human subjects, for example. Such images depicting parameters associated with nuclear spins (typically hydrogen protons associated with water in tissue) may be of medical diagnostic value in determining the state of health of tissue in the region examined. NMR techniques have also been extended to in vivo spectroscopy of such elements as phosphorus and carbon, for example, providing researchers with the tools, for the first time, to study chemical processes in a living organism. The use of NMR to produce images and spectroscopic studies of the human body has necessitated the use of specifically designed system components, such as the magnet, gradient and RF coils.
By way of background, the nuclear magnetic resonance phenomenon occurs in atomic nuclei having an odd number of protons and/or neutrons (i.e., a quantum mechanical asymmetry in the nucleus). Due to the spin of the protons and neutrons, each such nucleus exhibits a magnetic moment, such that, when a sample composed of such nuclei is placed in a static, homogeneous magnetic field, B
0
, a greater number of nuclear-magnetic moments align with the field to produce a net macroscopic magnetization M in the direction of the field. Under the influence of the magnetic field B
0
, the magnetic moments precess about the axis of the field at a frequency which is dependent on the strength of the applied magnetic field and on the characteristics of the nuclei. The angular precession frequency, w, also referred to as the Larmor Frequency, is given by the equation w=g B, in which g is the gyromagnetic ratio (which is constant for each NMR isotope) and wherein B is the magnetic field (B
0
plus other fields) acting upon the nuclear spins. It will be thus apparent that the resonant frequency is dependent on the strength of the magnetic field in which the sample is positioned.
The orientation of magnetization M, normally directed along the magnetic field B
0
, may be perturbed by the application of magnetic fields oscillating at or near the Larmor frequency. Typically, such magnetic fields designated B
1
are applied orthogonal to the direction of magnetization M by means of radio-frequency pulses through a coil connected to radio-frequency-transmitting apparatus. Magnetization M rotates about the direction of the B
1
field. In NMR, it is typically desired to apply RF pulses of sufficient magnitude and duration to rotate magnetization M into a plane perpendicular to the direction of the B
0
field. This plane is commonly referred to as the transverse plane. Upon cessation of the RF excitation, the nuclear moments rotated into the transverse plane begin to realign with the B
0
field by a variety of physical processes. During this realignment process, the nuclear moments emit radio-frequency signals, termed the NMR signals, which are characteristic of the magnetic field and of the particular chemical environment in which the nuclei are situated. The same or a second RF coil may be used to receive the signals emitted from the nuclei. In NMR imaging applications, the NMR signals are observed in the presence of magnetic-field gradients which are utilized to encode spatial information into the NMR signal. This information is later used to reconstruct images of the object studied in a manner well known to those skilled in the art.
In performing whole-body NMR studies, it has been found advantageous to increase the strength of the homogeneous magnetic field B
0
. This is desirable in the case of proton imaging to improve the signal-to-noise ratio of the NMR signals. In the case of spectroscopy, however, this is a necessity, since some of the chemical species studied (e.g., phosphorus and carbon) are relatively scarce in the body, so that a high magnetic field is necessary in order to detect usable signals. As is evident from the Larmor equation, the increase in magnetic field B is accompanied by a corresponding increase in w and, hence, in the resonant frequency of the transmitter and receiver coils. This complicates the design of RF coils which are large enough to accommodate the human body. One source of difficulty is that the RF field generated by the coil should be typically homogeneous over the body region to be studied. Another complication arises from the intrinsic distributed inductance and capacitance in such large coils which limit the highest frequency at which the coil can be made to resonate.
It is therefore an object of the invention to provide an electromagnetic resonance coil (e.g., an NMR, ESR on MRI coil). which is operable at lower power and/or which exhibits an improved signal-to-noise ratio, as desired for particular applications.
Although described with respect to the fields of NMR and MRI, it will be appreciated that similar advantages of lower power requirements and/or improved signal-to-noise ratio, as well as other advantages, may obtain in other applications of the present invention. Such advantages, may become apparent to one of ordinary skill in the art in light of the present disclosure or through practice of the invention.
SUMMARY OF THE INVENTION
The present invention includes electromagnetic resonators, a electromagnetic resonator devices, and electromagnetic resonance systems. The invention also includes analytical or diagnostic machines or instruments using those these aspects of the invention. Those analytical or diagnostic machines or instruments may include nuclear magnetic resonance (NMR) devices (for both liquid and solid state matter), electron spin resonance (ESR) devices, and magnetic resonance imaging (MRI) devices, of any type and as used for any purpose. The present invention may also be used to upgrade, repair or retrofit existing analytical or diagnostic machines or instruments of these types, using methods in components known in the art.
The present invention also includes analytical, diagnostic and testing methods and processes using the devices of the present invention. Examples of these methods include NMR (both liquid and solid state), ESR and MRI, as applied to any of the wide variety of matter in any of the physical states (including living and non-living tissue and organisms) to which these methods and processes have been or might be applied. The methods and processes of the present invention may be applied using procedures and protocols known and used in the arts to which they pertain.
In broadest terms, the electromagnetic resonator of the present invention comprises: (1) a sealed resonance cavity comprising at least one electromagnetic radiation port adapted to allow the passage of electromagnetic energy into and out of the cavity; and (2) at least one impedance matching element. In magnetic resonance applications, the electromagnetic resonator in use is disposed in proximity or within is a magnet such that the cavity is under the influence of the magnetic field.
As used herein, the term “sealed” refers to and should be understood as meaning the characteristics of a resonance cavity that is closed or otherwise obstructed so as to substantially reduce the amount of radiation emitting from the resonance cavity. It is preferred that radiation be substantially completely obstruc
Patidar Jay
Shrivastav Brij B.
Standley & Gilcrest LLP
The Ohio State University
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