Electricity: measuring and testing – Measuring – testing – or sensing electricity – per se – Frequency of cyclic current or voltage
Patent
1978-08-31
1980-12-16
Karlsen, Ernest F.
Electricity: measuring and testing
Measuring, testing, or sensing electricity, per se
Frequency of cyclic current or voltage
324 61R, G01R 2726
Patent
active
042400279
ABSTRACT:
A method for electromagnetic analysis of cellular or cell ghost physiology and pharmacology without disrupting the physcial integrity of the cell membrane is described. The method utilizes the technique of multifrequency automatic network analysis and signal processing to derive complex permittivities from the error corrected complex reflection coefficient of cell containing samples at each measured frequency. Complex permittivity at each frequency is then related to the dispersion in dielectric conductivity (a term which includes ohmic and non-ohmic losses) thereby measuring the ion permeability barrier and transport functions of the cell membrane and ion distribution inside of and outside of the cell membrane. The method measures the complex reflection coefficient of a capacitive termination containing a cellular sample as high frequencies are applied. Meaningful data can be developed in the range of frequencies of from 100 KHz to 100 MHz depending upon the exact nature of the cells and the automatic network analyzer used.
REFERENCES:
Stibitz et al., "A computer-Aided . . . ", Medical and Biological Engineeg, Jan. 1974, pp. 100-104.
Hyde, P. J., "Wide Frequency Range . . . ", Proc. of the IEE, vol. 117, No. 9, Sep. 1970, pp. 1891-1901.
Hewlett-Packard Catalog, 1970, pp. 386-388, Hewlett-Packard, Co., Palo Alto, Calif.
Jacobi John H.
Larsen Lawrence E.
Bellamy Werten F. W.
Gapcynski William G.
Karlsen Ernest F.
The United States of America as represented by the Secretary of
Winters Sherman D.
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