Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1985-06-24
1987-05-05
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
424153, 514 23, 514557, A61K 3119, A61K 3170, A61K 3314, A61K 3325
Patent
active
046631666
ABSTRACT:
Electrolyte solutions are provided which are useful in electrolyte and fluid therapy, parenteral nutrition, and dialysis. The Na:Cl ratio is normalized, plasma and cellular pH are normalized, and cellular cofactor ratios are normalized, in a manner which decreases toxicity over prior art solutions. The solutions employ at least one of the following near-equilibrium couples: (a) bicarbonate/CO.sub.2 ; (b) 1-lactate/pyruvate; and (c) d-betahydroxybutyrate/acetoacetate.
REFERENCES:
patent: 3970750 (1976-06-01), Brockemeyer et al.
patent: 3993750 (1976-11-01), Fox
Physicians' Desk Reference, 28th Ed. (1974), p. 125.
Latta, T., (1832), Malignant Cholera. Documents . . . Relative to the Treatment of Cholera by Copious Injection of Aqueous & Saline Fluids into the Veins, Lancet ii; 272-277.
Ringer, S., (1883), A Further Contribution Regarding the Influence of the Different Constituents of the Blood on the Contraction of the Heart, J. Physiol 4: 29-42.
Hartman, A. F., (1934), Theory & Practice of Parenteral Fluid Administration, JAMA 103: 1349-1354.
Locke, F. S., (1900), Die Wirkung der Metalle des Blutplasma & Verschiedener Zucker auf das Isolirte Saugerthierherz, Zentrablatt fuer Physiologie 14: 670-673.
Tyrode M.N., (1910), The Mode of Action of Some Purgative Salts, Arch. Int. Pharmacedyn. 20: 205-223.
Krebs H. A., Henseleit, K., (1932), Untersuchugen uber die Harnstoffbildung im Tierkorper, Hoppe-Seyler's Z Physiol. Chem. 210: 33-66.
Krebs, H. A., (1950), Body Size & Tissue Respiration, Biochem. Biophys. Acta 4: 249-269.
Dawson, A. M. C., Elliott, D., Elliott, W. H., Jone, K. M., (1969), Data for Biochemical Research 2nd Ed. Clarendon Press, Oxford, pp. 507, "Physiological Media".
Fox, Ch, Winfield, J. M., Slobody, L. B., Swindler C. M., Lattimer, J. K., (1952), Electrolyte Solution Approximating Plasma Concentrations with Increased Potassium for Routine Fluid & Electrolyte Replacement. JAMA 148: 827-833.
Mion, C. M., Hegstrom, R. M., Boen St, Scribner B. H., (1964), Substitution of Sodium Acetate for Sodium Bicarbonate in the Bath for Hemodialysis, Trans. Amer. Soc. Artif. Int. Organs 10: 110-113.
Parsons, F. M., Stewart, W. K., (1983), The Composition of Dialysis Fluid, In: Replacement of Renal Function by Dialysis , 2nd Ed. (Drukker, W., Parsons, F. M., Maher, J. F. eds), Martinus Nijhoff, Higham, pp. 148-170.
Facts and Comparisons, Oct. 1981-Aug. 1983. J. B. Lippincott; St. Louis 35d-53.
Documenta Geigy Scientific Tables (1962, Essellier, A. F., Jeanneret, P., Aqueous Solutions--Parenteral Infusion Therapy, pp. 331-334, Geigy Pharmaceutical Co., Ltd., Manchester.
Veech, R. L., Eggleston, L. V., Krebs, H. A., (1969), The Redox State of Free Nicotin Amide-Adenine Dinucleotide Phosphate in the Cytoplasm of Rat Liver Biochem. J. 115: 609-619.
Veech, R. L., Lawson, J. W. R., Cornell, N. W., Krebs, H. S., (1979), Cytosolic Phosphorylation Potential J. Biol. Chem. 254: 6538-6547.
Veech, R. L., Cook, G. A., King, M. T., (1980), Relationship of Free Cytoplasmic Pyrophosphate to Liver Glucose Content & Total Pyrophosphate to Cytoplasmic Phosphorylation Potential, FEBS Lett. 117: K65-K72.
Sistare, F. D., Haynes, R. C., Jr., (1985), The Interaction Between the Cytosolic Pyridine Mucleotide Redox Potential & Gluconeogenisis from Lactate/Pyruvate in Isolated Rat Hepatocytes, J. Biol. Chem. 260: 12748-12753.
Sistare, F. D., Haynes, R. C., Jr. (1985), Acute Stimulation by Gluconeogenisis from Lactate/Pyruvate in Isolated Hepatocytes from Normal and Adrenolectonized Rats, J. Biol. Chem. 260: 1254-12760.
Veech, R. L., (1986), The Toxic Impact of Parenteral Fluid Therapy, J. Clin. Nutr. (In Press).
Tauford, C. S., (1950), J. Am. Chem. Soc. 72: 441-451, Preparation & Properties of Serum Plasma Proteins, XXIII, Hydrogen Ion Equilibria in Nature & Modified Human Serum Albumin.
LandOfFree
Electrolyte solutions and in vivo use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Electrolyte solutions and in vivo use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Electrolyte solutions and in vivo use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2398618