Electrolyte solutions and in vitro use thereof

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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435 1, 435 2, 435241, 435260, 424127, 424128, 424153, 424154, 514 23, 514 2, C12N 500, A01N 102

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active

046632891

ABSTRACT:
Processes and compositions are provided for in vitro use in tissue culture media (preferred), perfusion media, and incubation media. Thus, balanced salt solutions are provided wherein the milliequivalent ratio of sodium cations to chloride anions is normalized and wherein optionally at least one near-equilibrium couple is incorporated (bicarbonate.sup.- /carbon dioxide, L-lactate.sup.- /pyruvate.sup.-, and d-betahydroxybutyrate.sup.- /acetoacetate.sup.-. Regulation of intracellular and extracellular pH, and normalization of intracellular redox state and phosphorylation state is achievable.

REFERENCES:
patent: Re30985 (1982-06-01), Cartaya
patent: 3122476 (1964-02-01), Gaeta
patent: 3128228 (1964-04-01), Michl
patent: 3356570 (1967-12-01), Butcher
patent: 3821368 (1974-06-01), Reynolds
patent: 3978212 (1976-08-01), Barna
patent: 3993751 (1976-11-01), Zinke
patent: 4018649 (1977-04-01), Cone, Jr.
patent: 4061537 (1977-12-01), Seiler
patent: 4186253 (1980-01-01), Yokoyama
patent: 4282326 (1981-08-01), Moldenhauer
patent: 4308255 (1981-12-01), Raj
patent: 4404192 (1983-09-01), Suzuki
patent: 4443432 (1984-04-01), Garabedian
patent: 4443546 (1984-04-01), Stemerman
patent: 4447415 (1984-05-01), Rock
patent: 4473647 (1984-09-01), Carpenter
patent: 4476221 (1984-10-01), Kane
patent: 4489535 (1984-12-01), Veltman
patent: 4508819 (1985-04-01), Rose
Latta, T., (1832), Malignant Cholera. Documents . . . Relative to the Treatment of Cholera by Copious Injection of Aqueous & Saline Fluids into the Veins, Lancet ii; 272-277.
Ringer, S., (1883), A Further Contribution Regarding the Influence of the Different Constituents of the Blood on the Contraction of the Heart, J. Physiol, 4: 29-42.
Hartman, A. F., (1934), Theory & Practice of Parenteral Fluid Administration, JAMA, 103: 1349-1354.
Locke, F. S., (1900), Die Wirkung der Metalle des Blutplasma & Verschiedener Zucker auf das Isolirte Saugerthierherz, Zentrablatt fuer Physiologie, 14: 670-673.
Tyrode, M. N., (1910), The Mode of Action of Some Purgative Salts, Arch int. Pharmacedyn, 20: 205-223.
Krebs, H. A., Henseleit, K., (1932), Untersuchugen Uber die Harnstoffbildung im Tierkorper., Hoppe-Seyler's Z Physiol Chem, 210: 33-66.
Dawson, A. M. C., Elliott, D., Elliot, W. H., Jone, K. M., (1969), Data for Biochemical Research, 2nd Ed., Clarendon Press, Oxford, p. 507, "Physiological Media".
Fox, Ch., Winfield, J. M., Slobody, L. B., Swindler, C. M., Lattimer, J. K. (1952), Electrolyte Solution Approximating Plasma Concentrations with Increased Potassium for Routine Fluid & Electrolyte Replacement, JAMA, 148, 827-833.
Mion, C. M., Hegstrom, R. M., Boen, St, Scribner, B. H., (1964), Substitution of Sodium Acetate for Sodium Bicarbonate in the Bath for Hemodialysis, Trans Amer Soc Artif Int. Organs, 10: 110-113.
Parsons, F. M., Stewart, W. K., (1983), The Composition of Dialysis Fluid. In: Replacement of Renal Function by Dialysis, 2nd ed. (Drukker, W., Parsons, F. M., Maher, J. F., eds), Martinus Nijhoff, Higham, pp. 148-170.
Facts and Comparisons, Oct. 1981-Aug. 1983, J. B. Lippincott: St. Louis, 35d-53.
Documenta Geigy Scientific Tables (1962 Essellier, A. F., Jeanneret, P., Aqueous Solutions-Parenteral Infusion Therapy. pp. 331-334, Geigy Pharmaceutical Co Ltd., Manchester.
Merck Manual, 12th Ed. (1972), Electrolytic, Caloric and Water Balance Agents. pp. 1866-1867.
Veech, R. L., Eggleston, L. V., Krebs, H. A., (1969), The Redox State of Free Nicotin Amide-Adenine Dinucleotide Phosphate in the Cytoplasm of Rat Liver, Biochem J, 115, 609-619.
Veech, R. L., Lawson, J. W. R., Cornell, N. W., Krebs, H. S., (1979), Cytosolic Phosphorylation Potential, J Biol Chem, 254: 6538-6547.
Veech, R. L., Cook, G. A., King, M. T., (1980), Relationship of Free Cytoplasmic Pyrophosphate to Liver Glucose Content & Total Pyrophosphate to Cyoplasmic Phosphorylation Potential, FEBS Lett, 117: K65-K72.
Sistare, F. D., Haynes, R. C., Jr., (1985), The Interaction Between the Cytosolic Pyridine Mucleotide Redox Potential & Gluconeogenisis from Lactate/Pyruvate in Isolated Rat Hepatocytes. J Biol Chem, 260, 12748-12753.
Sistare, F. D., Haynes, R. C., Jr., (1985), Acute Stimulation by Gluconeogenisis from Lactanate/Pyruvate in Isolated Hepatocytes from Normal and Adrenolectonized Rats. J Biol Chem, 260: 1254-12760.
Veech, R. L., (1986), The Toxic Impact of Parenteral Fluid Therapy, J Clin Nutr (In Press).
Tauford, C. S., (1950), J Am Chem Soc, 72: 441-451, Preparation & Properties of Serum Plasma Proteins. XXIII. Hydrogen Ion Equilibria in Nature & Modified Human Serum Albumin.

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