Electrokinetic instability micromixer

Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C204S454000, C204S547000, C204S601000, C204S643000, C137S896000

Reexamination Certificate

active

07070681

ABSTRACT:
A novel electrokinetic instability (EKI) micromixer and method takes advantage of the EKI to effect active rapid stirring of confluent microstreams of biomolecules without moving parts or complex microfabrication processes. The EKI is induced using an alternating current (A/C) electric field. Within seconds, the randomly fluctuating, three-dimensional velocity field created by the EKI rapidly and effectively stirs an initially heterogeneous solution and generates a homogeneous solution that is useful in a variety of biochemical and bioanalytical systems. Microfabricated on a glass substrate, the inventive EKI micromixer can be easily and advantageously integrated in molecular diagnostics apparatuses and systems, such as a chip-based “Lab-on-a-Chip” microfluidic device.

REFERENCES:
patent: 2949550 (1960-08-01), Brown et al.
patent: 5304487 (1994-04-01), Wilding et al.
patent: RE35102 (1995-11-01), Zare et al.
patent: 5716852 (1998-02-01), Yager et al.
patent: 5785831 (1998-07-01), Bek
patent: 6012902 (2000-01-01), Parce
patent: 6033546 (2000-03-01), Ramsey
patent: 6046056 (2000-04-01), Parce et al.
patent: 6082891 (2000-07-01), Schubert et al.
patent: 6086243 (2000-07-01), Paul et al.
patent: 6111096 (2000-08-01), Laugharn et al.
patent: 6158712 (2000-12-01), Craig
patent: 6174675 (2001-01-01), Chow et al.
patent: 6176962 (2001-01-01), Soane et al.
patent: 6210986 (2001-04-01), Arnold et al.
patent: 6213151 (2001-04-01), Jacobson et al.
patent: 6221226 (2001-04-01), Kopf-Sill
patent: 6235175 (2001-05-01), Dubrow et al.
patent: 6235471 (2001-05-01), Knapp et al.
patent: 6241379 (2001-06-01), Larsen
patent: 6287440 (2001-09-01), Arnold et al.
patent: 6306273 (2001-10-01), Wainright et al.
patent: 6337740 (2002-01-01), Parce
patent: 2002/0023841 (2002-02-01), Ahn et al.
A. Manz et al, “Electroosmotic pumping and electrophoretic separations for miniaturized chemical analysis systems.” J. Micromech. Microeng. 4, 257-265. (Dec. 1994).
M. H. Oddy et al.; “Electokinetic instability micromixing;” Analytical Chemistry, vol. 73, No. 24, Dec. 15, 2001, pp. 5822-5832.
J. G. Santiago; “Electroosmotic flows in microchannels with finite inertial and pressure forces;” Analytical Chemistry, vol. 73, No. 10, May 15, 2001, pp. 2353-2365.
Yi-Kuen Lee et al.; “Chaotic mixing in electrokinetically and pressure driven micro flows;” The 14thIEEE Workshop on MEMS Interlaken, Switzerland, Jan. 2001.
Pavlo Takhistov et al.; “Electrokinetic displacement of air bubbles in microchannels;” Jan. 29, 2001.
Jorg P. Kutter; “Current developments on electrophoretic and chromatographic separation methods on microfabricated devices;” trends on analytical chemistry, vol. 19, No. 6, 2000.
Robin H. Liu et al.; “Passive mixing in a three-dimensional serpentine microchannel;” Journal of Microelectromechanical Systems, vol. 9. No. 2, Jun. 2000.
Giles Hl Wl Sanders et al.; “Chip-based microsystems for genomic and proteomic analysis;” trends on analytical chemistry, vol. 19, No. 6, 2000.
Stephen C. Jacobson; “Microfluidic devices for electrokineticall parallel and serial mixing;” Analytical Chemistry, vol. 71, No. 20, Oct. 15, 1999, pp. 4455-4459.
M Koch et al.; “Two simple micromixers based on silicon;” J. Micomech. Microeng. 8 (1998) 123-126. Printed in the UK.
Dorian Liepmann et al.; “Micro-fluidic mixer;” Liepmann D.; Evans J. D. Polym. Mater. Sci. Eng. Proc. ACS Div. Polym. Mater. Sci. Eng. 1997, 76, pp. 549-550 Citation.
Norbert Schwesinger et al.; “A modular microfluid system with an integrated micromixer;” J. Micomech. Microeng. 6 (1996) 99-102. Printed in the UK.
J. Michael Ramsey et al.; “Microfabricated chemical measurement systems;” Nature Medicine, vol. 1, No. 10, Oct. 1995.
M Elwenspoek; “Towards integrated microliquid handling systems;” J. Micomech. Microeng. 4 (1994) 227-245. Printed in the UK.
J. M. Schneider et al.; “Electrohydrodynamic stability of space-charge-limited currents in dielectric liquids. I. Theoretical study;” The Physics of Fluids, vol. 13, No. 8, Aug. 1970.
J. R. Melcher et al.; “Electrohydrodynamics: a review of the role of interfacial shear stresses;” Melcher, J. R. :Tayler, G. I. Annu. Rev. Fluid Mech. 1969, I. 111-146.
Emilij K. Zholkovskij et al.; “Electokinetic instability of solution in a plane-parallel electrochemical cell;” Journal of Colloid and Interface Science 181, 28-33 (1996).
Kurt Seller et al.; “Electroosmotic pumping and valveless control of fluid flow within a manifold of capillaries on a glass chip;” Anal. Chem. Vol. 66, No. 20, Oct. 15, 1994, 3485-3491.
Jonathan Knight, “Honey, I shrunk the lab,” Nature/vol. 418 Aug. 1, 2002, pp. 474-475.
Chuan-Hua Chen et al., “Convective and absolute electrokinetic instability with conductivity gradients,” J. Fluid Mech. (2005), vol. 524, pp. 263-303.
Michael H. Oddy et al., “A Multiple-Species Model for Electrokinetic Instability,” Department of Mechanical Engineering, Stanford University, pp. 1-57.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Electrokinetic instability micromixer does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Electrokinetic instability micromixer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Electrokinetic instability micromixer will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3552973

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.