Electrochemiluminescence from acridan compounds

Details Electrochemiluminescence from acridan compounds Electrochemiluminescence from acridan compounds

2007-03-06

2007-03-06

Le, Long V. (Department: 1641)

Chemistry: analytical and immunological testing

Involving producing or treating antigen or hapten

Producing labeled antigens

C436S172000, C436S800000, C436S805000, C435S028000, C435S963000, C530S405000, C546S102000

Reexamination Certificate

active

10312401

ABSTRACT:
Methods are disclosed for producing electrochemiluminescence by electrochemically oxidizing an acridan compound at an electrode in the presence of a peroxide. Maintaining a sufficiently positive potential results in continuous oxidation of the acridan compound to an acridinium compound which reacts with peroxide to produce the luminescence. Light emission can be reversibly and repeatedly cycled on and off by sweeping the potential between two values. The acridan compounds can be provided with a labeling group for linking to an analyte or analyte binding partner. The present electrochemiluminescent reaction can find use in assay methods for detecting analytes by immunoassays and nucleic acid assays.

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