Electrochemiluminescence assays based on interactions with solub

Details Electrochemiluminescence assays based on interactions with solub Electrochemiluminescence assays based on interactions with solub

1997-06-02

1999-11-02

Soderquist, Arlen

Chemistry: analytical and immunological testing

Metal or metal containing

Cu, ag, au

436 73, 436 74, 436 83, 436 84, 436106, 436111, 436166, 436172, 2523895, 25238953, 25238954, 252390, 2524005, 25240053, 25240054, 252401, 252405, G01N 3320, G01N 3322, C09K 1532

Patent

active

059768878

ABSTRACT:
A novel electrochemiluminescent (ECL) reaction between diaminoaromatic ligands and soluble metal ions, specifically reactions between aminoaromatic ligands, such as 2,4-diaminotoluene (2,4,DAT), 3,4-diaminotoluene (3,4,DAT) and 2,3-diaminonaphthalene (2,3-DAN) and metal ions such as Au(I), Cu(II), Cr(VI), Fe(III), Ru)III), Se(IV) and V(V). Such reactions form the basis for ECL assays in detection of various substances, such as the reactants. The ECL interaction between these substances can also form the basis for binding methods in the detection of other substances, such as nucleic acids and antibodies wherein the metal ion ligand ECL complex may be used as a label. The ECL assays are considered useful for carrying out field and laboratory analyses for the detection of TNT breakdown products and toxic metals in wastewater streams, soil, and ground water supplies. In view of the formation of such ECL complexes being dependent on molecular size, further uses are contemplated for measuring atomic size or intermolecular distances of the complexes formed.

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