Surgery – Controlled release therapeutic device or system – Implanted dynamic device or system
Patent
1989-03-02
1989-12-12
Rosenbaum, C. Fred
Surgery
Controlled release therapeutic device or system
Implanted dynamic device or system
604 20, 604 96, A61K 922
Patent
active
048865141
ABSTRACT:
An electrochemically driven drug dispenser for dispensing a drug at a controlled rate. The drug dispenser includes an electrochemical pump which pumps an electrochemically active fluid from a first compartment through a membrane into a scond compartment. As the fluid enters the second compartment it exerts pressure on a diaphragm separating the second compartment from a chamber containing a drug to be administered. As the pressure increases, the drug is expelled. In the absence of any pumping action, the fluid moves between the two compartments by diffusion through the membrane at a rate which is characteristic of the membrane and determined by any pressure difference between the two compartments. The pumping rate is determined by the magnitude of an electric current applied to the pump, and by varying the pumping rate with reference to the diffusion rate any of a variety drug administration rates can be implemented. A pressure sensor may be included in the pump for more precise control of the pumping rate. The membrane may be fabricated of electrolytic and non-electrolytic portions so that a desired diffusion rate can be achieved.
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patent: 4718893 (1988-01-01), Dormon et al.
Electroosmotic Pump for the Uniform, Regulated or Controlled Release of Drugs, G. Luft, D. Kuhl, G. J. Richter.
IVAC Corporation
Rose Sharon
Rosenbaum C. Fred
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