Electrochemical solid phase synthesis

Details Electrochemical solid phase synthesis Electrochemical solid phase synthesis

1998-01-05

2000-07-25

Gorgos, Kathryn

Electrolysis: processes, compositions used therein, and methods

Electrolytic coating

Coating selected area

C25D 502

Patent

active

06093302&

ABSTRACT:
A solid phase synthesis method for the preparation of diverse sequences of separate polymers or nucleic acid sequences using electrochemical placement of monomers or nucleic acids at a specific location on a substrate containing at least one electrode that is preferably in contact with a buffering or scavenging solution to prevent chemical crosstalk between electrodes due to diffusion of electrochemically generated reagents.

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patent: 5810989 (1998-09-01), Krihak et al.
Gildea, Brian D. et al., "A Versatile Acid-labile Linker for modification of Synthetic BioMolecules" Tetrahedron Letters vol. 31:No.49:pp. 7095-7098 (1990) no month avail.
Livache, Thierry et al., "Polypyrrole DNA Chip on a Silicon Device: Example of Hepatitis C Virus Genotyping" Analytical Biochemistry 255: 188-194 (1998) no month avail.
Meo, Tommaso, et al., "Monoclonal antibody to the message sequence TryGly-Gly-Phe of optoid peptides exhibits the specificity requirements of mammalian optoid receptors", Proc. Natl. Acad. Sci USA 80: 4084-4088 (1983) Jul. 1983.
Merrifield, J. Am. Chem. Soc. 85:2149-2154 (1963) Jul. 20, 1963.

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