Electrochemical process for the preparation of sulphoxides of th

Details Electrochemical process for the preparation of sulphoxides of th Electrochemical process for the preparation of sulphoxides of th

1983-06-16

1984-08-21

Andrews, R. L.

Chemistry: electrical and wave energy

Processes and products

C25B 302

Patent

active

044668660

ABSTRACT:
Sulphoxides of thioformamide derivatives of the formula: ##STR1## wherein R represents hydrogen or a C.sub.1 -C.sub.4 alkyl radical, Het represents a heterocyclic radical selected from pyridin-3-yl (optionally substituted by a C.sub.1 -C.sub.4 alkyl radical or by a halogen atom), quinolin-3-yl, pyridazin-4-yl, pyrimidin-5-yl, thiazol-5-yl, thieno[2,3-b]pyridin-5-yl and thieno[3,2-b]pyridin-6-yl, and Y represents a valency bond or a methylene radical, are prepared by oxidizing the ring sulphur atom of a thioformamide derivative of the general formula: ##STR2## by an electrochemical method. The reaction is carried out in an electrolyte with a considerable water content, at a pH of between 7 and 7.5 and in the presence of a specific oxidizing agent X.sup.+ obtained in situ from a halide X.sup.- by an electrochemical method, and at an imposed electrode potential similar to the oxidation potential of X.sup.-.
The sulphoxide products are useful as medicaments for treating hypertension.

REFERENCES:
patent: 3418224 (1968-12-01), Bennett et al.
patent: 4219393 (1980-08-01), Torii et al.

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