Chemistry: electrical and wave energy – Apparatus – Electrophoretic or electro-osmotic apparatus
Patent
1997-08-22
2000-04-04
Beisner, William H.
Chemistry: electrical and wave energy
Apparatus
Electrophoretic or electro-osmotic apparatus
204601, G01N 2726
Patent
active
060456760
ABSTRACT:
A microfabricated capillary electrophoresis chip which includes an integral thin film electrochemical detector for detecting molecules separated in the capillary.
REFERENCES:
patent: 4891120 (1990-01-01), Sethi et al.
patent: 5071531 (1991-12-01), Soane
patent: 5126022 (1992-06-01), Soane
patent: 5194133 (1993-03-01), Clark et al.
patent: 5429734 (1995-07-01), Gajar et al.
patent: 5580435 (1996-12-01), Kovacs
Gavin, Peter F., et al.; "Continuous Separations with Microfabricated Electrophoresis-Electrochemical Array Detection",J. Am. Chem. Soc. (1996), vol. 118, pp. 8932-8936.
Adam T. Woolley, et al., Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips, Proc. Natl. Acad. Sci., vol. 91, pp. 11348-11352, Nov. 1994, Biophysics.
Mark K. Shigenaga, et al., In Vivo Oxidative DNA Damage. . ., Methods in Enzymology, vol. 186, pp. 521-530, 1994.
Dan Wu, et al., Electrophoretically mediated micro-assay of alkaline phosphatase using electrochemical and spectrophotometric detection in capillary electrophoresis, Journal of Chromatography D, 656 (1994) pp. 357-363.
Dean H. Johnston, et al., Electrochemical Measurement of the Solvent Accessibility of Nucleobases Using Electron Transfer between DNA and Metal Complexes, J. Am. Chem. Soc. 1995, 117, pp. 8933-8938.
Teresa M. Olefirowicz, et al., Capillary Electrophoresis in 2 and 5 .mu.m Diameter Capillaries: Application to Cytoplasmic Analysis, Anal. Chem. 1990, 62, pp. 1872-1876.
Karin Pihel, et al., Electrochemical Detection of Histamine and 5-Hydroxytryptamine at Isolated Mast Cells, Anal. Chem. 1995, 67 pp. 4514-4521.
Fu-Ren F. Fan, et al., Electrochemical Detection of Single Molecules, Science, vol. 267, Feb. 10, 1995, pp. 871-874.
Shigeori Takenaka, et al., Electrochemically Active DNA Probes: Detection of Target DNA Sequences at Femtomole Level . . ., Analytical Biochemistry 218, (1994), pp. 436-443.
D. E. Smith, et al., Second Harmonic Alternating Current Polarography with a Reversible Electrode Process, Analytical Chemistry, vol. 33, No. 4, Apr. 1961, pp. 482-485.
Phillip D. Voegel, et al., Electrochemical detection with copper electrodes in liquid chromatography and capillary electrophoresis, American Laboratory, Jan. 1996, pp. 39-45.
Jonathan M. Slater, et al., On-chip Microband Array Electrochemical Detector for use in Capillary Electrophoresis, Analyst, Nov. 1994, vol. 119, pp. 2303-2307
Andrew G. Ewing, et al., Electrochemical Detection in Microcolumn Separations, Analytical Chemistry, vol. 66, No. 9, May 1, 1994, pp. 527A-536A.
Xiaohua Huang, et al., On-Column Conductivity Detector for Capillary Zone Electrophoresis, Analytical Chemistry, vol. 59, No. 23, Dec. 1, 1987, pp. 2747-2749.
Mei-Cheny Chen, et al., An Electrochemical Cell for End-Column Amperometric Detection in Capillary Electrophoresis, Analytical Chemistry, vol. 67, No. 21, Nov. 1, 1995, pp. 4010-4014.
Thomas J. O'Shea, et al., Capillary electrophoresis with electrochemical detection employing an on-column Nafion joint, Journal of Chromatography, 593, (1992), pp. 309-312.
Adam T. Woolley, et al., Ultra-High Speed DNA Sequencing Using Capillary Electrophoresis Chips, Anal. Chem. 1995, 67, pp. 3676-3680.
Glazer Alexander N.
Lao Kaigin
Mathies Richard A.
Woolley Adam T.
Beisner William H.
The Board of Regents of the University of California
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