Electrochemical detector cell

Chemistry: electrical and wave energy – Apparatus – Electrolytic

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Details

204412, 204416, 422 8201, 422 8203, 73 6157, 73 6158, 73 6161, G01N 2726, G01N 2100, G01N 3102

Patent

active

053992563

ABSTRACT:
An electrochemical detector cell includes a first block having a planar first working surface, and a first working electrode embedded in the first block member. The first working electrode includes analyte contacting surface disposed co-planarly with the first working surface. A second block member has the second working surface placeable in an opposed, adjacent relation to the first working surface, and has an inlet port disposed an opposed, adjacent relation to the analyte contacting surface of the first working electrode. The second block also includes a coupling means for permitting an analyte delivery tube to be coupled to the second block member to position an end of the analyte delivery tube adjacent to the inlet port. A generally circular circumferential channel for collecting analyte is disposed radially outwardly of the first working electrode. An outlet is disposed at the channel for conducting analyte away from the channel. A reference electrode is disposed in a diametrically opposed relation to the outlet, and a ring-like gasket is placeable between the first and second block members for maintaining the first and second working surfaces in a predetermined spaced relation. The gasket includes a radially inner diameter disposed radially outwardly of the channel. The inlet port, channel, first working electrode, first working surface, second working surface, gasket and outlet port are configured to create a generally centrosymmetric thin layer radial flow path for the analyte across the working electrode, and between the first and second working surfaces, into the channel and out of the outlet port.

REFERENCES:
patent: 3997420 (1976-12-01), Buzza et al.
patent: 4059406 (1977-11-01), Fleet
patent: 4092233 (1978-05-01), Clemens et al.
patent: 4404065 (1983-09-01), Matson
patent: 4496454 (1985-01-01), Berger
patent: 4554064 (1985-11-01), McClintock et al.
patent: 4628463 (1986-12-01), Sturrock et al.
patent: 4911794 (1990-03-01), Parce et al.
patent: 5031499 (1991-07-01), Kuwana et al.
Kissinger, Biomedical Applications of Liquid Chromatography-Electrochemistry, J. Chromatography 488 (1989), pp. 31-52 no month available.
Shoup, Brunlett, Jacobs & Kissinger: ICEC: A Powerful Tool for Biomedical Problem Solving, American Lab., Oct. 1981.
Hoogvliet, Elferink, Van Der Poel & Van Bennekom, "Design & Characterization of An Electrochemical Ring-Disk Flow" through Detector for Liquid Chromatography; Analytica Chimica Acta, 153 (1983) 199-159 no month available.
Fleet and Little, J. Chromatography, 12 (1974) pp. 747-752 no month available.
H. Bunasinghm, "Analytical Application of the Wall Jet Detector", Trends in Anal. Chem. v. 7 No. 6 (1988) no month available.
Scudder, Pollema & Ruzicka, "The Fountain Cell: A Tool for Flow-Based Spectroscopies," Anal. Chem. 1992, v. 64 pp. 2657-2660 no month available.
Shoup, "Liquid Chromatography/Electrochemistry" High Performance Liquid Chromatography, Advances and Perspectives, vol. 4, ed. CSABA Horvath, (1986) Academic Press, pp. 121-135 no month available.
Webber & Purdy, "Electrochemical Detection With a Regenerative Flow Cell in Liquid Chromatography", Analytical Chem. (1982) v. 54 p. 1757 no month available.
McClintock & Purdy, "Dual Working Electrode Electrochemical Detector for Liquid Chromatography" Analytica Chimica Acta 148 (1983) pp. 127-133 no month available.
Bratin & Kissinger, "Glassy-Carbon Amperometric Transducers as Electrochemical Detectors in Liquid Chromatography" Talanta, v. 29 pp. 365-370 (1982) no month available.
Kissinger, Bruntlett et al, "Liquid Chromatography with Electrochemical Detection" State of the Art and Future Directions, NBS Special Publication, Trace Organic Analysis: A New Frontier in Anal. Chem. (1978) Proc. of 9th Materials Res. Sympos. 10-13 Apr. 1978.
Kissinger, Bratin, et al, "The Potential Utility of Pre-and Post Column Chemical Reactions in the Electrochemical Detection in Liquid Chromatography", J. Chromat. Sci, 17 (1979) pp. 137-146 no month available.
Kissinger, "Amperometric & Coulometric Detectors for High Performance Liquid Chromatography" Anal Chem. 49 (1977) p. 447A no month available.
Roston, Shoup, Kissinger, "Liquid Chromatography/Electrochemistry Thin Layer Multiple Electrode Detection", Anal. Chem., 54 (1982) pp. 1417A-1434A no month available.
Lunte, Radzik & Kissinger, "An Introduction to the Study of Xenobiotic Metabolism Using Electroanalytical Techniques" J. Pharmaceutical Sciences, 79 (1990) p. 557 no month available.
Davis & Kissinger, "Strategies for Determination of Serum or Plasma Norepinephrine by Reverse Phase Liquid Chromatography", Anal. Chem. 53 (1981) pp. 156-159 no month available.
Kissinger, Bruntlett & Shoup, "Neurochemical Application of Liquid Chromatography with Electrochemical Detection", Life Sciences, 28 (1981) pp. 455-465 no month available.
Bratin, Kissinger et al. "Determination of Nitro, Aromatic, Nitramine and Nitrate Ester Explosive Compounds in Explosive Mixtures and Gunshot Residue by Liquid Chromatography and Reductive Electrochemical Detection", Analytica Chimica Acta, 130 (1980) pp. 295-311 no month available.
Shoup & Kissinger, "Determination of Urinary Normetanephrine, Metanephrine, and 3-Metroxytry Amino by Liquid Chromatography, with Amperometric Detection", Clin. Chem. 23 (1977) pp. 1268-1274 no month available.
Lunte, Kissinger & Shoup, "Difference Mode Detection with Thin Layer Dual Electrode Liquid Chromatography/Electrochemistry", Anal Chem, 57 (1985) pp. 1541-1546 no month available.
Kissinger, "Determination of Biogenic Aminos and Their Metabolites by Liquid Chromatography/Electrochemistry", Methods in Biogenic Amino Research, (1983) pp. 75-99 no month available.
Kissinger & Pachla, "Determination of Ascorbic Acid and Dehydroascorbic Acid Using Liquid Chromatography with Ultraviolet and Electrochemical Detection", Food Technology, Nov. 1987 pp. 108-111.

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