Electrolysis: processes – compositions used therein – and methods – Electrolytic analysis or testing – Involving enzyme or micro-organism
Patent
1994-12-29
1997-03-11
Tung, T.
Electrolysis: processes, compositions used therein, and methods
Electrolytic analysis or testing
Involving enzyme or micro-organism
204403, 204418, 435817, 436806, G01N 27327
Patent
active
056097492
ABSTRACT:
An enzyme electrode, specific binding or the like electrochemical assay method capable of performing always stably high detection sensitivity (responsibility) and reappearance even in the case of blood, urine and the like samples that contain interfering substances and also of applying suitably to disposable use, and a novel p-phenylenediamine compound which is used in the assay method. Particularly, an electrochemical assay method in which a substance in a liquid sample is assayed using at least one oxidoreductase, wherein an oxidoreductase, an electron mediator and an electrode which performs electron transfer with the mediator are arranged in the assay system, and a compound of the following formula [I] or a salt thereof is used as the mediator which is highly soluble in water, dried (by freeze-, vacuum- or air-drying) easily and stable under dry condition, shows a high electron transfer rate with enzymes and is almost free from the influence of interfering substances in blood, urine and the like samples: ##STR1## wherein R.sup.1 to R.sup.4 may be the same or different from one another and each means a hydrogen, a straight- or branched-chain alkyl group having 1 to 4 carbon atoms, optionally having a substituent, providing that at least one of R.sup.1 to R.sup.4 has one or more groups selected from hydroxyl, mercapto, carboxyl, phosphonooxy and sulfo.
REFERENCES:
patent: 5286362 (1994-02-01), Hoenes et al.
patent: 5371131 (1994-12-01), Gierenz et al.
Chemical Abstracts, vol. 96, No. 18, Abstract No. 152685x, p. 677 (1982) mouth unavailable.
Chemical Abstracts, vol. 83, No. 17, Abstract No. 148369m, p. 50 (1975) month unavailable.
Coury, Jr. et al, Anal. Chem., 65, pp. 242-246 (1993) month unavailable.
Willems et al, Photographic Science and Engineering, vol. 6, No. 1, pp. 39-48 (1962) month unavailable.
Chopoorian et al, Nature, vol. 204, pp. 180-181 (Oct. 10, 1964).
Uhlig et al, Z. Chem., vol. 4, No. 11, pp. 436 (1964) month unavailable.
Uhlig et al, Z. Chrm., vol. 4, No. 12, pp. 463-465 (1964) month unavailable.
Rios et al, An. Quin., Ser. B, vol. 59, No. 7-8, pp. 501-506 (1963) month unavailable.
Rios et al, An Quin., Ser. B., vol. 61, No. 5, pp. 717-722 (1965) month unavailable.
Rios et al, An. Quin., Ser. B., vol. 61, No. 5, pp. 723-728 (1965) month unavailable.
Rios et al, An. Quin., Ser. B., vol. 59, No. 7-8, pp. 493-500 (1963) month unavailable.
Mederos et al, An. Quin., Ser. B., vol. 82, No. 2, pp. 133-139 (1986) month unavailable.
Research Disclosure, vol. 212, pp. 428-432 (Dec. 1981).
Terasawa Hideyuki
Yamauchi Tadakazu
Mochida Pharmaceutical Co. Ltd.
Tung T.
LandOfFree
Electrochemical assay method with novel p-phenylenediamine compo does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Electrochemical assay method with novel p-phenylenediamine compo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Electrochemical assay method with novel p-phenylenediamine compo will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-440461