Electro-release systems, modified electrodes and their use

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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424449, A61F 202, A61F 1302

Patent

active

061327522

ABSTRACT:
This invention relates to modified electrodes their manufacture and use, to electro-release systems including such electrodes for electro-release of compounds, for example medical or veterinary pharmaceutical compounds, and to methods for electro-release. By electro-release is meant that the electrochemical release of the compound, or the inhibition of such release, is caused by the application of an appropriate voltage bias to an electrode. Such a system allows accurate control of timing and/or amount of release.

REFERENCES:
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patent: 4994023 (1991-02-01), Wellinghoff et al.
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Pickett et al, "Bioinorganic reaction centres on electrodes. Modified electrodes possessing amino acid, peptide and ferrodoxin-type groups on a poly(pyrrole) backbone", J. Chem. Soc., Dalton Transactions, 2181-2189.
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Picket et al, "Synthesis and Anodic Polymerisation of an L-Cystine derivatised Pyrrole; Copolymerization with a Tetraalkylammonium Pyrrole allows Reduction of the Cystinyl Film to a Cysteinyl State that Binds Electroactive {Fe.sub.4 S.sub.2 }.sup.2+ Centres", J. Chem. Soc. Chem. Commun. 9:694-697 (1992).
Pickett et al, "Iron Sulfur Clusters in Ionic Polymers on Electrodes", J. Chem. Soc. Dalton Trans., pp. 3695-3703 (1993).
Picket and Ryder, "Bioinorganic Reaction Centres on Electrodes. Modified Electrodes possessing Amino Acid, Peptide and Ferredoxin-type Groups on a Poly(pyrrole) Backbone", J. Chem. Soc. Dalton Trans., pp. 2181-2189 (1994).
Ibrahim et al, "Peptide derivatised poly(pyrrole) modified electrodes with built-in ion-exchange functions", Journal of Electroanalytical Chemistry 387:139-142 (1995).

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