Electro-osmotically driven liquid delivery method and apparatus

Details Electro-osmotically driven liquid delivery method and apparatus Electro-osmotically driven liquid delivery method and apparatus

1997-06-18

1999-08-24

Phasge, Arun S.

Chemistry: electrical and wave energy

Processes and products

Electrophoresis or electro-osmosis processes and electrolyte...

204600, 204601, 204603, 204604, G01N 2700

Patent

active

059420936

ABSTRACT:
Method and apparatus for controlling precisely the composition and delivery of liquid at sub-.mu.L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-.mu.L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column.

REFERENCES:
patent: 5378334 (1995-01-01), Dadoo et al.
patent: 5441613 (1995-08-01), McCormick et al.
patent: 5545303 (1996-08-01), Schasfoort et al.
patent: 5573651 (1996-11-01), Dasgupta et al.
patent: 5585069 (1996-12-01), Zanzucchi et al.

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