Electro-optical devices and methods for hybridization and...

Details Electro-optical devices and methods for hybridization and... Electro-optical devices and methods for hybridization and...

2006-05-23

2006-05-23

Sisson, Bradley L. (Department: 1634)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C435S006120, C435S810000, C436S073000, C436S094000, C436S182000, C536S023100, C536S024300, C536S025320

Reexamination Certificate

active

07049129

ABSTRACT:
The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to form an initial complex, a metal ion for doping the initial complex and forming a final complex, and a potential means for providing a potential to the final complex to produce a detectable signal indicating the presence of the target after redox reaction. The method of the invention teaches the steps of hybridizing a probe with an attached label to the target to produce an initial complex, adding a metal ion to the initial complex to form a final complex and applying a potential to the final complex to produce a measurable signal.

REFERENCES:
patent: 5591578 (1997-01-01), Meade et al.
patent: 5686244 (1997-11-01), Gudibande et al.
patent: 5714089 (1998-02-01), Bard et al.
patent: 5945344 (1999-08-01), Hayes et al.
patent: 5952172 (1999-09-01), Meade et al.
patent: 6048687 (2000-04-01), Kenten et al.
patent: 6140138 (2000-10-01), Bard et al.
patent: WO 99/31115 (1999-06-01), None

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