Electro-optical device and methods for hybridization and...

Details Electro-optical device and methods for hybridization and... Electro-optical device and methods for hybridization and...

2006-04-18

2006-04-18

Sisson, Bradley L. (Department: 1634)

Chemistry: analytical and immunological testing

Heterocyclic carbon compound

Hetero-o

C436S800000, C436S805000, C435S006120, C536S023100, C536S024300

Reexamination Certificate

active

07029919

ABSTRACT:
The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to form an initial complex, a metal ion for doping the initial complex and forming a final complex, and a potential means for providing a potential to the final complex to produce a detectable signal indicating the presence of the target after redox reaction. The method of the invention teaches the steps of hybridizing a probe with an attached label to the target to produce an initial complex, adding a metal ion to the initial complex to form a final complex and applying a potential to the final complex to produce a measurable signal.

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Hammershoi et al., Journal of Inorganic Biochemistry, (Mar. 1993) vol. 49, No. 4, pp. 295-304; abstract only.
Zu et al., Analytical Chemistry, vol. 72, No. 14, Jul. 15, 2000, pp. 3223-3232.

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