Electrically controllable, non-occluding, body implantable drug

Surgery – Controlled release therapeutic device or system – Implanted dynamic device or system

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6048921, A61N 130

Patent

active

050411071

ABSTRACT:
An implantable apparatus for continuous or periodic introduction of a drug to a desired release point in the body comprises an implantable power source and an elongated flexible plastic tubular catheter having a lumen filled with the drug to be delivered and containing therein a first device electrode. The distal end of the catheter is closed and located near the distal end is a port which extends through the wall of the catheter to communicate with the lumen. Just proximal of the port is a surface electrode mounted on the exterior wall of the catheter body. Extending through the catheter and joined to the drive electrode and the surface electrode are conductors which couple those electrodes to the implanted power source. Energization of the electrodes with a predetermined direct current potential causes a flow of the ionized drug molecules out through the port and into the area surrounding the surface electrode.

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Studies on Surgical Adjuvant Chemotherapy for Colorectal Cancer and Administration of Neocarzinostatin into the Lumen of the Colon or Rectum Using a Double Balloon Catheter and Iontophoresis, by Shunji Akao, Arch. Jpn. Chir 50:67-82, Jan. 1981.
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