Electrical sensing circuitry for particle analyzing device

Details Electrical sensing circuitry for particle analyzing device Electrical sensing circuitry for particle analyzing device

1973-08-13

1976-03-16

Smith, Alfred E.

Electricity: measuring and testing

Determining nonelectric properties by measuring electric...

Erosion

324 30R, 324 64, G01N 2700, G01N 2742, G01R 2714

Patent

active

039449173

ABSTRACT:
The electrical sensing circuitry includes a power supply and a signal-detecting circuit which are coupled through the resistance of an electrolyte in a liquid in an aperture of a particle-analyzing device between sensing electrodes positioned on either side of the aperture. The liquid containing an electrolyte and the passage of a liquidborne particle through the aperture causes a change in the resistance of the aperture thereby generating a signal which is detected by the signal-detecting circuit. The parameters of the circuit elements are chosen to provide circuit relationships which render the particle-generated signal independent of the diameter of the aperture. This is achieved by utilizing a power source having a low output impedance and a signal-detecting circuit which has a low input impedance for both D.C. and A.C., namely, at the signal frequencies of the signals sensed. The electrical circuitry also may include a conductivity monitoring circuit which may utilize one or more of the sensing electrodes and/or additional electrodes for monitoring changes in conductivity of the electrolyte and for relating these changes in conductivity to the particle-generated signals sensed by the signal-detecting circuit to alter those signals so as to render them independent of electrolyte resistivity.

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Bebyakov, A.N., "Physicochemical Measurements..." USSR Journal - Izmeritel'naya Tekhnika, No. 8, Aug. 1972, pp. 58-60.
Leif, R.C. and Thomas, R.A., "Electronic Cell-Volume Analysis...", Clinical Chemistry, No. 8, Vol. 19, 1973, pp. 853-870.
"Automated Cell Identification and Cell Sorting, editing G.L. Wied and G.F. Bahr, published in 1970, pp. 139-146.
C.M.Boyd and G.W. Johnson, "Studying Zoo Plankton Populations..." Marine Technical Society of America, 1968, pp. 83-90.

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