Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1987-06-05
1991-03-19
Naff, David M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
204403, 435 20, 435177, 435288, 435817, 436528, 436151, 436806, 530812, C12Q 100, C12N 1102, G01N 33544, C12M 140
Patent
active
050010484
ABSTRACT:
An electrical biosensor for analyte determination is prepared by polymerization of a mixture of a biological receptor capable of binding an analyte in a sample, a protein and a polymerizing agent such as glutaraldehyde to form a polymeric film on a transducer. The mixture preferably contains a stabilizer selected from lipids, detergents and antioxidents. The receptor may be an acetylcholine receptor and the analyte, acetylcholine. A preferred stabilizer is a combination of phosphatidyl choline and octyphenoxypolyethoxyethanol. In carrying out a determination, analyte in a sample binds to the receptor causing a change in an electrical characteristic of the film which is indicative of the presence of the analyte. The biosensor may contain a second polymeric film that is free of the receptor and which serves as a control.
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Cook Edward J.
Marenchic Ingrid G.
Taylor Richard F.
Aurthur D. Little, Inc.
Naff David M.
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