Elastomer, its preparation and use

Details Elastomer, its preparation and use Elastomer, its preparation and use

1998-11-12

2000-05-02

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

528 15, 524588, 424484, A61K 914

Patent

active

06056976&

ABSTRACT:
The invention relates to a siloxane-based elastomer intended for controlling the permeation of drugs, wherein the elastomer includes 3,3,3,-trifluoropropyl groups attached to the Si-atoms of the siloxane units.
The invention relates also to a method for the preparation of a siloxane-based elastomer including 3,3,3,-trifluoropropyl substituents, where the elastomer is intended for controlling the permeation of drugs.
In the method either
i) a 3,3,3,-trifluoropropyl-substituted vinyl-functional polysiloxane component and a silicon hydride-functional crosslinking agent are crosslinked in the presence of a catalyst, or
ii) a 3,3,3,-trifluoropropyl-substituted polysiloxane component is crosslinked in the presence of a peroxide catalyst.

REFERENCES:
patent: 3050492 (1962-08-01), Polmanteer et al.
patent: 3179619 (1965-04-01), Brown
patent: 3854480 (1974-12-01), Zaffaroni
patent: 5492993 (1996-02-01), Saam et al.
patent: 5733569 (1998-03-01), Moo-Young et al.
patent: 5824736 (1998-10-01), Kobayashi et al.

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