Measuring and testing – Liquid analysis or analysis of the suspension of solids in a... – Vapor pressure
Patent
1980-06-16
1982-03-02
Howell, Kyle L.
Measuring and testing
Liquid analysis or analysis of the suspension of solids in a...
Vapor pressure
G01N 3348
Patent
active
043173632
ABSTRACT:
An elastometer for measuring the mechanical strength of biological gels such as blood or fibrin clots. Thus this device may be used for accessing anticoagulant and fibrinolitic activities, particularly with respect to drug evaluation. The instrument can also be used to study abnormalities in the blood clotting process, i.e. for clinical diagnosis purposes. The elastometer instrument consists primarily of four basic components: (1) a main body frame including a sample cup holder having a channel therein for circulating fluid to maintain constant temperature of the testing sample; (2) a sample disk and transducer core assembly concentrically suspended in the sample cup by a thin steel wire from an accurate positioning device or micro-manipulator; whereby clots are formed in the gap between the sample cup and the sample disc; (3) an electromagnetic device for applying variable amounts of shear stress via the sample disk to the sample; and (4) a transducer assembly for measuring displacement of the sample subject to a specified shear stress. The instrument includes specially designed clamps for supporting the wire from which the sample disk and transducer core assembly are suspended and precisely adjustable slide assemblies for critical positioning and control of the transducer and electromagnets.
REFERENCES:
patent: 3714815 (1973-02-01), Hartert
patent: 4045999 (1977-09-01), Palmer
patent: 4148216 (1979-04-01), Do et al.
patent: 4193293 (1980-03-01), Cavallari
patent: 4202204 (1980-05-01), Hartert
Hermans, J. Jr., Investigation of Elastic Properties of Hydrocolloids, Journal of Poly. Sci., Part A, vol. 3, pp. 1859-1868, 1965.
Carr, N. E. et al., A Physical Standard of Fibrinogen, In Anal. Bio. 72, pp. 202-211, 1976.
Shen, L. L. et al., Differential Activities of Heparins in Plasma, Thrombosis Research, 13, pp. 671-679, 1978.
Abbott Laboratories
Fato Gildo E.
Howell Kyle L.
Niblack Robert L.
Roskos Joseph W.
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