Elastase-inhibiting peptides bearing a C-terminal trifluoromethy

Details Elastase-inhibiting peptides bearing a C-terminal trifluoromethy Elastase-inhibiting peptides bearing a C-terminal trifluoromethy

1993-11-30

1995-07-04

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, 564153, 544164, 544168, A61K 3806

Patent

active

054300258

ABSTRACT:
Trifluoromethylketone compounds of the formula: ##STR1## wherein R.sup.1 is C.sub.1-6 alkyl which has one or two substituents selected from carboxy, esterified carboxy and di-C.sub.1-6 alkylcarbamoyl; phenyl(C.sub.1-6)alkyl, the phenyl moiety of which may have halogen or nitro or amino substituents and the alkyl moiety of which may have carboxy or esterified carboxy substituents; halo-phenyl; morpholino; or morpholino(C.sub.1-6)alkyl, R.sup.2 and R.sup.3 are each C.sub.1-6 alkyl, X is --or --NH--, and ##STR2## and pharmaceutically acceptable salts thereof are useful for inhibiting human elastase.

REFERENCES:
patent: 4910190 (1990-03-01), Bergeson
patent: 5296591 (1994-03-01), Hemmi
Skiles et al., Chemical Abstracts, 116(11), 1992, Abst. No. 106736y.

Affiliated with

Also associated with

Rating

Elastase-inhibiting peptides bearing a C-terminal trifluoromethy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Elastase-inhibiting peptides bearing a C-terminal trifluoromethy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Elastase-inhibiting peptides bearing a C-terminal trifluoromethy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-760225