Elaiophylin derivatives, the use thereof as pharmaceuticals, and

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514384, 514397, 514424, 514450, 514452, 514460, 514444, 548251, 548255, 5482632, 548336, 548517, 548519, 549267, 549 60, 536 41, A61K 3141, C07D40900

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active

049854518

ABSTRACT:
The invention relates to elaiophylin derivatives of the formula I, II and III ##STR1## in which the substituents R(1), R(2), R(3) and R(3)' have the specified meanings. The compounds have antibacterial and antiviral activity.

REFERENCES:
patent: 4216233 (1980-08-01), Clayton et al.
patent: 4364956 (1982-12-01), Clark et al.
patent: 9166863 (1979-09-01), Luk et al.
Seebach et al. "(+-11,11'-li-O-Methylelarophylidese, Preparation from Elasophylin and Total Synthesis from (R)-3-Hydroxybutyrate and (S)-Malate", CA 105: 152790 g (1986).
D. Seebach et al., Liebigs Ann. Chem., 1281-1308 (1986).
W. Keller-Schierlein et al., Helv. Chim. Acta, 64(41):407-424 (1981).
S. Takashashi et al., Chem. Pharm. Bull., 15(11):1651-1656, 1657-1661, 1726-1732 (1967).

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