Eicosatriynoic acid esters and amides and methods of preparation

Details Eicosatriynoic acid esters and amides and methods of preparation Eicosatriynoic acid esters and amides and methods of preparation

1993-05-17

1994-05-10

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554 68, 554150, 554151, 554154, 554158, 554159, C07C231100

Patent

active

053109597

ABSTRACT:
Processes for preparing 5,8,11-eicosatriynoic acid as well as esters and amides thereof involves initially preparing the acid by reacting 1-decyne with 1,4-dihalo-2-butyne in the presence of a strong base to form 1-halo-2,5-tetradecadiyne which is then reacted with 5-hexynoic acid so as to form 5,8,11-eicosatriynoic acid. This acid can then be converted to the acid chloride form and reacted with an alcohol to form an ester or converted to a potassium salt and reacted with a halide also to form an ester, or after conversion to an acid chloride reacted with an amine in the presence of a tertiary amine to form an amide, or the acid can be reacted with carbonyldiimidazole in the presence of a solvent and excess amine to form an amide.

REFERENCES:
Chemical Abstracts, vol. 100, #19, 1983, 156200j.

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