Eicosapentaenoic acids and methods for their production

Details Eicosapentaenoic acids and methods for their production Eicosapentaenoic acids and methods for their production

1990-03-21

1993-09-14

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

A61K 3120

Patent

active

052449211

ABSTRACT:
This invention describes a process for producing single cell edible oils containing eicosapentaenoic acid (EPA) from heterotrophic diatoms. The diatoms are cultivated in a fermentor in a nutrient solution containing nitrogen and silicate. Withdrawal of the nitrogen followed by withdrawal of the silicate induces the diatoms to synthesize large quantities of edible oil containing EPA which subsequently is recovered. The edible oil, and uses for it, also form parts of this invention as do mutant diatoms capable of producing large quantities of EPA.

REFERENCES:
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patent: 4615839 (1986-10-01), Seto et al.
patent: 4670285 (1987-06-01), Clandinin et al.
patent: 4831022 (1989-05-01), Hijiya et al.
Biosis 88081708 (1989)--Volkman et al.
Biosis 85008909 (1987)--Vladivostok.
Yazawa et al. J. Biochem, 103: 5-7 (1988).
Borowitzka, "Micro-Algal Biotechnology", Cambridge University Press (1988).
Miller et al., LIPIDS, 24:998-1003.
Hoeksema et al., "An EPA-Containing Oil From Microalgae In Culture" paper presented at Int'l Conference in St. Johns, Canada Jul. 31-Aug. 2, 1988.
Li et al., Br. Phycol. J. 22: 375-382.
Behrens, et al. "Novel Microbial Products for Medicine and Agriculture", Society for Industrial Microbiology (1989).

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