Eicosapentaenoic acids and methods for their production

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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A61K 3120

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active

052449211

ABSTRACT:
This invention describes a process for producing single cell edible oils containing eicosapentaenoic acid (EPA) from heterotrophic diatoms. The diatoms are cultivated in a fermentor in a nutrient solution containing nitrogen and silicate. Withdrawal of the nitrogen followed by withdrawal of the silicate induces the diatoms to synthesize large quantities of edible oil containing EPA which subsequently is recovered. The edible oil, and uses for it, also form parts of this invention as do mutant diatoms capable of producing large quantities of EPA.

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Miller et al., LIPIDS, 24:998-1003.
Hoeksema et al., "An EPA-Containing Oil From Microalgae In Culture" paper presented at Int'l Conference in St. Johns, Canada Jul. 31-Aug. 2, 1988.
Li et al., Br. Phycol. J. 22: 375-382.
Behrens, et al. "Novel Microbial Products for Medicine and Agriculture", Society for Industrial Microbiology (1989).

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