Eicosapentaenoic acid used to treat cachexia

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514557, 514573, A61K 3119, A61K 3120

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active

054571308

ABSTRACT:
The use of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid or EPA, preferably substantially free of any other polyunsaturated fatty acids, is disclosed for making up medical preparations or compositions for the treatment of cachexia by inhibiting lipolytic activity of biologically active lipolytic agents present in body fluids and the activity of the enzyme guanidinobenzoatase, as well as for reducing abnormal cAMP levels in cells of adipose tissue in mammals, produced by lipolytic or fat mobilizing substances.

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Laustiola et al, Biochimica et Biophysica Acta, vol. 889, 1986, Elsevier Science Publishers B.V.
Karmall et al, J.N.C.J., vol. 73, No. 2, Aug., 1984.
Begin et al, Prostaglandins Leukotrienes and Medicine, vol. 19, 1985.
Booyens et al, IRCS Medical Science, vol. 14, No. 4, 1986.
Steven et al, J. Enzym. Inhib., vol. 1, No. 2, 1987.

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