Ehrlichia canis 120-kDa immunodominant antigenic protein and gen

Details Ehrlichia canis 120-kDa immunodominant antigenic protein and gen Ehrlichia canis 120-kDa immunodominant antigenic protein and gen

1998-08-27

2000-03-28

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 691, 435 701, 435 711, 435 712, 4353201, 435455, 435326, 435410, 4352523, 43525411, 43525233, 4352551, 435362, 530350, 536 231, 536 235, 536 237, 536 242, C12N 1500, C12N 120, C12N 114, C12N 116

Patent

active

060430850

ABSTRACT:
The present invention provides a 120-kDa protein gene of Ehrlichia canis, amplified by PCR using primers derived from the DNA sequences flanking the Ehrlichia chaffeensis 120-kDa protein gene. The recombinant E. canis 120-kDa protein contains 14 tandem repeat units with 36 amino acids each. The repeat units are hydrophilic and predicted to be surface-exposed. Also disclosed is that the recombinant E. canis 120-kDa protein is antigenic and reacts with sera from dogs convalescent from canine ehrlichiosis.

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Campbell Lab. Tech. Biochem. Molec. Biolo. vol. 23 edited by van der Vliet, 1991.

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