Ehk and Ror tyrosine kinases

Details Ehk and Ror tyrosine kinases Ehk and Ror tyrosine kinases

1995-06-06

1998-12-01

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

536 235, 536 2351, C12N 1554, C07K 14435

Patent

active

058437495

ABSTRACT:
The present invention provides for novel receptor tyrosine kinases known as Ror-1, Ror-2, Ehk-1 and Ehk-2. The invention also provides for assay systems that may be used to detect and/or measure neurotrophin activity or to identify agents that exhibit neurotrophin-like activity. It is based, at least in part, on the discovery that the trkB proto-oncogene encodes a tyrosine kinase receptor that may serve as a functional binding protein for BDNF and NT-3. The present invention also provides for diagnostic and therapeutic methods based on the interaction between BDNF and/or NT-3 and trkB.

REFERENCES:
patent: 5457048 (1995-10-01), Pasquale et al.
Sajjadi, et al, "Five novel avian Eph-related tyrosine kinases are differentially expressed", Oncogene 8, (Jul., 1993), pp. 1807-1813.

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