Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2002-03-12
2003-11-04
Henley, III, Raymond (Department: 1761)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C424S581000, C426S330100
Reexamination Certificate
active
06642202
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to a composition having an active oxygen eliminating ability, more specifically to a composition having an active oxygen eliminating ability that comprises, as an active ingredient, an egg from Aves containing iodine.
BACKGROUND OF THE INVENTION
It is conventionally said that active oxygen has a harmful toxicity against vital tissues, and is considered to be an important cause of the development of various diseases such as skin aging, cancers, apoplectic stroke, rheumatism, etc. (Seikagaku Jiten (Biochemical Dictionary), the 2
nd
edition, p.699, Feb. 5, 1991, Tokyo Kagaku Dozin Co., Ltd.; Iwanami Rikagaku Jiten (Iwanami Physical and Chemical Dictionary), the 3
rd
edition (enlarged edition), p.749, Feb. 20, 1986; U.S. Pat. No. 4,022,224; Japanese Patent Application Laying-Open (Kokai) No. 63-79834)
Examples of active oxygen known to be generated in vivo include superoxide anion radical, hydrogen peroxide, hydroxy radical, single oxygen, and peroxy radical or alkoxy radical that is generated by hyperoxidation of lipids. It is known that these active oxygens bring about crosslinking of collagen fibers, damage to DNA molecules, or damage to tissues due to chain radical generation, against the organism, and as a result, these become causes for aging of skin or body, elicitation of inflammation, damage to the smooth muscle in myocardial infarct, hepatopathy, dementia due to disruption of brain tissues, or provocation of cancerogenesis.
Accordingly, it is considered that elimination of active oxygen generated in vivo is important for prevention or treatment of these diseases. It is considered that especially elderly people have a degraded biophylactic ability, which is an ability to protect the body from oxidation-stress disorder of DNA molecules, and so supplementation of an antioxidant substance from outside the body is necessary. In respect of a method of supplementing such a substance, there is a high expectation for the antioxidant action of many antioxidant substances such as polyphenol present in foods (Chojyushoku no Science (Science of Longevity Food), p.223, Sep. 29, 2000, Science Forum Co., Ltd.)
From this viewpoint, the search for a substance which eliminates active oxygen has been performed broadly.
Japanese Patent Examined Publication (Kokoku) No.5-19531 discloses an active oxygen controlling composition, which is obtained by adding microorganisms to plant seeds or embryos roasted with far infrared radiation for fermentation, and further adding vegetable oil obtained from roasted plants thereto. Plants exemplified in this publication are grain crops such as rice, wheat and barley, and pulses such as soybean and corn. Moreover, Japanese Patent Application Laying-Open (Kokai) No. 6-128121 discloses that a water extract or organic solvent extract of Asparathus linearis water has an active oxygen eliminating action.
Thus, various things have been proposed, which control the action of active oxygen, but these are mainly natural materials, extracts or additives thereof. In respect of livestock products, there is only a report indicating that products from livestock, to which extruder-processed soybean-mixed feed were provided, have an active oxygen eliminating action, a product which was developed by the inventor (Japanese Patent Application No. 2000-231016). This indicates that an active oxygen eliminating ability is observed in products from livestock, when livestock were fed with feed mixed with raw materials having an active oxygen eliminating ability, but this does not refer to livestock products obtained by feeding livestock with feed mixed with raw materials not having an active oxygen eliminating ability.
Furthermore, techniques of allowing livestock products to have a functionality by devising feed are disclosed in Japanese Patent Application Laying-Open (Kokai) Nos. 2000-125781, 11-155495 and 10-056978. However, livestock products having an active oxygen eliminating ability, which are obtained as a result of mixing raw materials not having an active oxygen eliminating ability, into feed, have not been disclosed in any of these publications regarding prior art.
SUMMARY OF THE INVENTION
The object of the present invention is to impart to eggs originally having almost no active oxygen eliminating ability, a strong active oxygen eliminating ability.
While the present inventors, in connection with eggs, essential foods in daily life, have studied about the effect of minor components added to feed on an egg component and the effect of the egg component on life habit diseases, they have found that an egg containing a high level of iodine has an ability to eliminate active oxygen which harmfully acts on the human body.
That is to say, the present invention relates to,
(1) A composition for elimination of active oxygen which comprises, as an active ingredient, an egg having 4.2 ppm or more iodine,
(2) A food or drink which comprises the composition for elimination of active oxygen according to (1) above,
(3) A method for producing an egg for elimination of active oxygen, which comprises administration of more than a certain amount of iodine compound and/or seaweed to Aves, so that an egg thereof comprises 4.2 ppm or more iodine, and
(4) The production method according to (3) above, wherein the iodine compound is one or more selected from calcium iodate, potassium iodate and potassium iodide.
An active ingredient of the composition of the present invention, “an egg containing a high level of iodine”, can generally be obtained as follows.
An iodine compound such as calcium iodate, potassium iodate, potassium iodide, sodium iodate, thymol iodide, copper iodide, diiodo salicylate or calcium periodate; seaweed containing a large amount of iodine such as Laminaria or kelp; or a processed product thereof is mixed into feed at more than a certain amount, and then the mixture is administered to Aves so as to increase the content of iodine in an egg thereof. In this case, it is preferable to use one or more selected from calcium iodate, potassium iodate and potassium iodide in terms of health of birds, transfer rate of iodine into eggs thereof, etc., and it is further preferable to use seaweed such as Laminaria in combination.
The amount of iodine administered to Aves depends on types of Aves, i.e. fowls, quails, etc., but in the case of an egg-laying hen, about 5 to 250 mg, preferably about 5 to 15 mg per hen per day may be administered. Generally, iodine is mixed into feed for administration, and in that case, estimating that a hen consumes about 100 g of feed per day, 50 to 2,500 ppm, desirably 50 to 150 ppm of iodine may be mixed into the feed.
As stated above, where a substance containing a large amount of iodine was administered to Aves, an egg containing a large amount of iodine of interest is laid after about a week. In the case of an egg-laying hen, for example, where feed containing about 50 ppm of iodine is administered, an egg containing about 300 &mgr;g of iodine can be obtained, and where feed containing about 100 ppm of iodine is administered thereto, an egg containing about 600 to 800 &mgr;g of iodine can be obtained.
Usually, the amount of iodine required for an egg-laying hen is 0.30 to 0.35 mg per kg of feed (according to NRC), and the actual amount of iodine in commercially available feed is 0.3 to 2.0 mg/kg. The amount of iodine in a ordinary egg laid from a hen fed with this commercially available feed is about 6 &mgr;g (according to the American Egg Board), and at most, the amount is about 30 &mgr;g per egg. Almost no active oxygen eliminating ability is observed in such a ordinary egg. When compared with this normal egg, since the egg obtained as above contains a remarkably high level of iodine, it has an active oxygen eliminating ability.
The thus obtained egg containing a high level of iodine can be used as the composition of the present invention, as is, or can be subjected to a processing such as heating, drying, concentration, pulverization or granulation. Moreover, it can be used in a form of a table
Kashimori Ayuko
Matsuki Akiko
Sekimoto Kunitoshi
Fish & Richardson P.C.
Henley III Raymond
Nosan Corporation
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