EGFR inhibitors promote axon regeneration

Details EGFR inhibitors promote axon regeneration EGFR inhibitors promote axon regeneration

2005-07-12

2008-11-11

Kemmerer, Elizabeth C. (Department: 1649)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C424S143100

Reexamination Certificate

active

07449442

ABSTRACT:
Compositions and methods for promoting neural regeneration in a patient determined to have a lesion in a mature CNS neuron are disclosed. The method comprises the step of contacting the neuron with an EGFR inhibitor sufficient to promote regeneration of the neuron.

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Koprivica et al. EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science. Oct. 7, 2005; 310(5745):106-10.
Miller. Neuroscience. Cancer drugs may help injured nerve cells regrow their axons. Science. Oct. 7, 2005 ;310(5745):31.

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