EGF variants and pharmaceutical use thereof

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.

Patent

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Details

435 691, 435 701, A61K 3736, A61K 3710, C12P 2106

Patent

active

052180930

ABSTRACT:
Biologically active variants of epidermal growth factor are provided, comprising tandemly linked units of monomeric EGF. The variants are useful per se as therapeutic agents to promote wound healing. Production of the multimeric EGF by genetically engineered microbial hosts is also described.

REFERENCES:
patent: 4764593 (1988-08-01), Banks et al.
patent: 4783524 (1988-11-01), Larsen et al.

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