EGF receptor truncates

Details EGF receptor truncates EGF receptor truncates

1990-10-26

1993-06-08

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 691, 4352523, 536 235, C07K 1300, C12N 1512

Patent

active

052180905

ABSTRACT:
The present invention is for EGF receptor truncates which retain the activity of ligand binding for the EGF receptor. The specific truncates include LD.sub.1 D.sub.2 D.sub.3.Apa L encompassing amino acids Met.sub.-24 to Val.sub.505 of the EGF receptor; for LD.sub.2 D.sub.3 D.sub.4 which melds the EGF receptor leader peptide (amino acids Met.sub.-24 to Ala.sub.-1), 9 amino acids of the mature amino terminus of the receptor (Leu.sub.1 to Gly.sub.9) and receptor sequences Ser.sub.150 to Gly.sub.625 ; for LD.sub.3 D.sub.4 which is the leader peptide (Met.sub.-24 to Ala.sub.-1), Leu.sub.1 to Gln.sub.8 of the mature amino terminus and the receptor sequence Asp.sub.297 to Gly.sub.625.

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