Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1989-02-24
1990-07-31
Robinson, Ellis P.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424 11, 264 43, A61K 3722
Patent
active
049449486
ABSTRACT:
A composition and method for treating a wound or surgical incision, by sustained-released delivery of epidermal growth factor (EGF). The composition includes a high-viscosity aqueous dispersion of negatively charged liposomes with liposome-entrapped EGF. The EGF/liposome composition is formed, in one embodiment of the invention, by suspending a lipid mixture typically containing equimolar amounts of neutral and negatively charged phopholipids and cholesterol in a low-conductivity aqueous medium containing EGF and a zwitterionic compound whose isoelectric point is between pH 5.5 and 8.5 to form a gel-like composition. One embodiment of the invention contains EGF entrapped by surface adsorption to the liposomes, for slow release from the composition.
REFERENCES:
patent: 4781871 (1988-11-01), West, III et al.
Brown, G. L., et al., Ann. Surg. 208 (6) p. 788 (1988).
Mayhew, E., et al., Exp. Cell Res. 171 p. 195 (1987).
Buckley, A., et al., Proc. Natl. Acad. Sci. USA 82 p. 7340 (1985).
Fielding Robert M.
Martin Francis J.
Uster Paul S.
Dehlinger Peter J.
Liposome Technology, Inc.
Prater P. C.
Robinson Ellis P.
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