Eg5 co-crystals

Details Eg5 co-crystals Eg5 co-crystals

2004-12-20

2010-02-16

Steadman, David J (Department: 1656)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C702S027000, C703S011000, C435S004000, C435S007400, C435S007600, C435S183000, C435S195000

Reexamination Certificate

active

07662581

ABSTRACT:
This invention provides methods of identifying an Eg5 binding ligand. The ligand is identified by using the atomic coordinates of an Eg5 crystal to generate a three dimensional structure. The three dimensional structure is used in molecular modeling techniques and docking experiments to identify ligands that bind to the binding pocket of Eg5. A novel binding pocket is identified. The invention also provides a crystallized Eg5 and ligand complex.

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